Email this article Influence of Toxic Combustion Products on the State of Intestinal Microbiota in the Pathogenesis of Non-Alcoholic Fatty Liver Disease in Firefighters
- Authors: Gatsura V.Y.1, Gumanenko K.E.2, Sannikov M.V.3, Kriyt V.E.4, Pyatibrat E.D.5, Pyatibrat A.O.2
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Affiliations:
- Occupational Health Facility, the Ministry of Internal Affairs for the City of St. Petersburg and the Leningrad region
- St. Petersburg State Pediatric Medical University
- Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
- North Western Centre for Hygiene and Public Health
- S.M.Kirov Military Medical Academy
- Issue: No 1 (2022)
- Pages: 59-65
- Section: Clinical Aspects of Disaster Medicine
- URL: https://ogarev-online.ru/2070-1004/article/view/360221
- DOI: https://doi.org/10.33266/2070-1004-2022-1-59-65
- ID: 360221
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Abstract
Abstract. Medical and psychological support of professional activity of firefighters does not take into account their chronic poisoning by toxic products of burning. Such diagnoses are made to the firefighters of the State Fire Service of the Federal Fire Service of EMERCOM of Russia only in case of acute poisoning. Insufficient attention paid to the impact of fire-specific toxicants, including dioxins, does not allow timely detection of disturbances in the regulation of physiological systems of firefighters’ organisms, which leads to the emergence of diseases.
The aim of the study was to determine the effect of dioxins on the state of the microbiota.
Materials and research methods. The study involved 246 male patients, of whom 121 were employees of the State Fire Service of the Federal Fire Service of EMERCOM of Russia and 125 were civilians and rescuers of EMERCOM of Russia.
Research results and their analysis. The data obtained in the study of the blood microbiota by chromatography-mass spectrometry of microbial markers indicate a pronounced intestinal dysbiosis in firefighters with non-alcoholic fatty liver disease due to decreased number of microbial markers of the normal microbiota along with increased total number of microbial markers and opportunistic microorganisms.
The dysbacteriosis revealed in the firefighters having no health complaints can be a predictor of liver pathology development that testifies to necessity of control and timely correction of microecological status.
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About the authors
V. Y. Gatsura
Occupational Health Facility, the Ministry of Internal Affairs for the City of St. Petersburg and the Leningrad region
Email: a5brat@yandex.ru
St. Petersburg
K. E. Gumanenko
St. Petersburg State Pediatric Medical University
Email: a5brat@yandex.ru
St. Petersburg
M. V. Sannikov
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Email: a5brat@yandex.ru
St. Petersburg
V. E. Kriyt
North Western Centre for Hygiene and Public Health
Email: a5brat@yandex.ru
St. Petersburg
E. D. Pyatibrat
S.M.Kirov Military Medical Academy
Email: a5brat@yandex.ru
St. Petersburg
A. O. Pyatibrat
St. Petersburg State Pediatric Medical University
Email: a5brat@yandex.ru
Dr. Sci. (Med.), Associate Prof. 2, Litovskaya str., St. Petersburg, 194100, Russia
References
- Kriyt V.E., Sannikov M.V., Sladkova Yu.N., Pyatibrat A.O. Influence of Xenobiotic Detoxication Gene Polymorphisms and Experience on the Level of Accumulation of Dioxins in Emercom of Russia Employees. Mediko-Biologicheskiye i Sotsial’no-Psikhologicheskiye Problemy Bezopasnosti v Chrezvychaynykh Situatsiyakh = Medico-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2020;2:55–68. doi: 10.25016/2541-7487-2020-0-2-55-68 (In Russ.).
- Abu-Shanab A., Quigley E.M. The Role of the Gut Microbiota in Nonalcoholic Fatty Liver Disease // Nat. Rev. Gastroenterol Hepatol. 2010;7:691–701.
- Mouzaki M., Comelli E.M., Arendt B.M., Bonengel J., Fung S.K., Fischer S.E., et al. Intestinal Microbiota in Patients with Nonalcoholic Fatty Liver Disease. Hepatology. 2013;58:120–127. doi: 10.1002/hep.26319.
- Nieuwdorp M., Gilijamse P.W., Pai N., Kaplan L.M. Role of the Microbiome in Energy Regulation and Metabolism. Gastroenterology. 2014;146:1525–1533. doi: 10.1053/j.gastro.2014.02.008.
- Zhu L., Baker S.S., Gill C., et al. Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis (NASH) Patients: a Connection Between Endogenous Alcohol and NASH. Hepatology. 2013;57;2:601–609.
- Chernyak Yu.I., Grassman J.A. Impact of AhRR (565C>G) Polymorphism on Dioxin Dependent CYP1A2 Induction. Toxicology Letters. 2020;320:58-63.
- Viluksela M., Unkila M., Pohjanvirta R., Tuomisto J.T., Stahl B.U., Rozman K.K., et al. Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Liver Phosphoenolpyruvate Carboxykinase (PEPCK) Activity, Glucose Homeostasis and Plasma Amino Acid Concentrations in the Most TCDD-Susceptible and the Most TCDD-Resistant Rat Strains. Arch. Toxicol. 1999;73;6:323–336.
- Osipov G.A., Demina A.M. Chromato-Mass Spectrometric Detection of Microorganisms in Anaerobic Infectious Processes. Vestnik RAMN = Annals of the Russian Academy of Medical Sciences. 1996;3;2:52–59 (In Russ.).
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