Assessment of the relationship of salivary and serum homocysteine levels with coronary artery stenosis
- Authors: Petrov M.V.1, Burmistrova L.F.1, Timofeev D.M.1, Burmistrov M.E.1, Komissarenko I.A.2
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Affiliations:
- Penza State University
- A.I. Evdokimov Moscow State University of Medicine and Dentistry
- Issue: Vol 22, No 4 (2025)
- Pages: 43-49
- Section: Original Researches
- URL: https://ogarev-online.ru/1994-9480/article/view/375644
- DOI: https://doi.org/10.19163/1994-9480-2025-22-4-43-49
- ID: 375644
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Abstract
A number of studies demonstrate the association of hyperhomocysteinemia with cardiovascular pathology. However, a number of unresolved questions remain regarding the correlation of serum and saliva homocysteine and their relationship to the lipid profile and severity of coronary artery stenosis.
Aim: To evaluate the relationship of saliva and serum homocysteine levels with the lipid profile and the degree of coronary artery stenosis.
Material and methods: 2 groups of subjects were formed: group 1 included 45 patients with stable angina pectoris of 3 FC, group 2–39 practically healthy individuals of comparable gender and age. The parameters of the general blood test, lipid profile, the level of homocysteine, vitamin B12, serum folic acid and saliva, as well as coronary angiography data were evaluated.
Results: In both groups, a positive correlation was determined between serum and saliva homocysteine (control group: r = 0.64, p < 0.001; CHD group: r = 0.71, p < 0.001). Significant correlations were found between serum and saliva homocysteine and lipid profile parameters such as total cholesterol and LDL cholesterol. Sufficiently high indicators of sensitivity, specificity and accuracy were obtained within the framework of the diagnostic value of homocysteine for determining the severity of coronary artery stenosis, the AUC of serum homocysteine was 0.703; saliva homocysteine was 0.659. In general, the obtained values were comparable for saliva and serum.
Conclusion: A positive correlation between serum and saliva homocysteine was determined in the group of practically healthy individuals and in the group of patients with coronary heart disease. Significant correlations were found between serum and saliva homocysteine and lipid profile parameters such as total cholesterol and LDL cholesterol. Sufficiently high indicators of sensitivity, specificity and accuracy were obtained within the framework of the diagnostic value of serum and saliva homocysteine to determine the severity of coronary artery stenosis. The AUC of serum homocysteine was 0.703; saliva homocysteine was 0.659.
About the authors
Mikhail V. Petrov
Penza State University
Author for correspondence.
Email: mikh.petrov1@yandex.ru
ORCID iD: 0000-0003-0542-4040
Candidate of Medical Sciences, Associate Professor of the Department of Polyclinic Therapy and Mobilization Training in Healthcare
Russian Federation, PenzaLarisa F. Burmistrova
Penza State University
Email: lamax-69@mail.ru
ORCID iD: 0000-0002-6568-0305
PhD, Associate Professor, Department of Polyclinic Therapy and Mobilization Training in Healthcare
Russian Federation, PenzaDaniil M. Timofeev
Penza State University
Email: daniltimofeev112@gmail.com
ORCID iD: 0000-0002-1546-4794
Postgraduate student at the Faculty of Medicine
Russian Federation, PenzaMaxim E. Burmistrov
Penza State University
Email: lamax-69@mail.ru
ORCID iD: 0000-0001-9000-1565
Resident of the Faculty of Medicine
Russian Federation, PenzaIrina A. Komissarenko
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Email: komisarenko@mail.ru
ORCID iD: 0000-0001-5621-2721
MD, Professor of the Department of Therapy and Preventive Medicine
Russian Federation, MoscowReferences
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