电邮这篇文章 Current treatment options for dry eye syndrome in children
- 作者: Kovaleva L.A.1, Kuznetsova T.V.1, Baisangurova A.A.1, Zaitseva A.A.1
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隶属关系:
- Helmholtz National Medical Research Center of Eye Diseases
- 期: 卷 19, 编号 1 (2024)
- 页面: 15-24
- 栏目: Original study article
- URL: https://ogarev-online.ru/1993-1859/article/view/254279
- DOI: https://doi.org/10.17816/rpoj623620
- ID: 254279
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AIM: To analyze personalized therapy for dry eye syndrome (DES) in children, depending on the etiopathogenesis and severity of the disease.
MATERIAL AND METHODS: In total, 187 children aged 3–17 years with DES were treated. Ophthalmic medicines registered in Russia from the group of local rehydrants replacing tear fluid and stabilizing tear film were used, and a comparative analysis of their effectiveness was carried out.
RESULTS: An individual approach was implemented, and personalized therapy focused on the individual tolerability and effectiveness of medicines was developed. The principle of DES therapy is to replenish the lacrimal fluid deficiency and stabilize all layers of the tear film, considering the etiopathogenesis and severity of clinical symptoms. At this stage, the lipid layer of the tear film was normalized with the help of hypotonic oil-based preparations that can stabilize the lipid layer. All rehydrants of low, medium, and high viscosities contributed to the restoration of the water layer of the joint venture. The deficiency of the mucin layer of the tear film was compensated by hyaluronic acid and carboxymethylcellulose, which are part of the preparations that replace the tear film. The severity of DES associated with the intensity of the clinical changes in the conjunctiva and cornea was considered when designing the DES treatment regimen in children. In cases of mild and extremely severe severity, tear-replacement medicines of low viscosity showed the greatest therapeutic effectiveness. High-viscosity preparations and gels have been proven to be effective in moderate to severe DES. During the desquamation of the conjunctival and corneal epithelium, medicines with regenerating pharmacological action related to tissue repair simulators were included in the treatment regimen. Reparants included in the combined composition of tear-replacement medicines or monopreparations were used.
CONCLUSION: The effectiveness of the DES treatment algorithm in children with various nosologies and features of etiopathogenesis was analyzed considering disease severity. The proposed schemes of personalized tear-replacement and reparative therapy make it possible to prevent a chronic disease course and occurrence of complications and preserve or restore visual acuity.
作者简介
Ludmila Kovaleva
Helmholtz National Medical Research Center of Eye Diseases
编辑信件的主要联系方式.
Email: ulcer.64@mail.ru
ORCID iD: 0000-0001-6239-9553
SPIN 代码: 1406-5609
MD, Cand. Sci. (Medicine)
俄罗斯联邦, MoscowTatjana Kuznetsova
Helmholtz National Medical Research Center of Eye Diseases
Email: tatakuzn@gmail.com
ORCID iD: 0009-0005-1333-2420
SPIN 代码: 4815-6968
MD, Ophthalmologist
俄罗斯联邦, MoscowAlbina Baisangurova
Helmholtz National Medical Research Center of Eye Diseases
Email: alia-bai-5@mail.ru
ORCID iD: 0000-0002-8014-667X
SPIN 代码: 2308-0920
MD, Ophthalmologist
俄罗斯联邦, MoscowAlina Zaitseva
Helmholtz National Medical Research Center of Eye Diseases
Email: alisha_klin@mail.ru
ORCID iD: 0000-0001-8852-3305
SPIN 代码: 8965-1586
MD, Ophthalmologist
俄罗斯联邦, Moscow参考
- Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017;15(3):276–283. doi: 10.1016/j.jtos.2017.05.008
- Jones L, Downie LE, Korb D, et al. TFOS DEWS II management and therapy report. Ocul Surf. 2017;15(3):575–628. doi: 10.1016/j.jtos.2017.05.006
- Milner MS, Beckman KA, Luchs JI, et al. Dysfunctional tear syndrome: dry eye disease and associated tear film disorders — new strategies for diagnosis and treatment. Curr Opin Ophthalmol. 2017;27 Suppl 1(Suppl 1):3–47. doi: 10.1097/01.icu.0000512373.81749.b7
- Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II Epidemiology Report. Ocul Surf. 2017;15(3):334–365. doi: 10.1016/j.jtos.2017.05.003
- Brzhesky VV, Somov EE. «Dry eye» syndrome in patients with congenital glaucoma. Russian Journal of Clinical Ophthalmology. 2003;4(3):139–141. (In Russ).
- Astasheva IB. Features of the state of the lacrimal system and the stability of the precorneal film in premature infants. Modern problems of pediatric ophthalmology. Materials of the Anniversary Scientific Conference Dedicated to the 70th Anniversary of the Founding of the First Department of Pediatric Ophthalmology in Russia; 2005; St. Petersburg, Russia. St. Petersburg; 2005. P. 210–212. (In Russ).
- Biryukova NV, Nesterova NV, Uvarov AA. The impact of distance learning on the health of teachers, schoolchildren and students. Collection of articles of the 5th International Scientific and Practical Conference «Innovative trajectory of the development of modern science: formation, development, forecasts»; 2021 Jan 11; Petrozavodsk, Russia. Petrozavodsk; 2021. P. 149–154. (In Russ). doi: 10.46916/14012021-1-978-5-00174-110-7
- Somov EE, Saidasheva EI. «Dry eye» syndrome in children. In: Pediatric ophthalmology: results and prospects. Moscow; 2006. P. 342–343. (In Russ).
- Nagorsky PG, Belkina VV, Nesterova LYu. The impact of tear replacement therapy (hylabak 0.15% eye drops) on the extent of dry eye syndrome in children and adolescents wearing contact lenses. Russian Ophthalmological Journal. 2011;4(2):32–36. (In Russ).
- Katargina LA, Shestova YuP, Denisova EV. «Dry eye» syndrome with endogenous uveitis in children. 5th Russian National Ophthalmological Forum: collection of scientific papers of a scientific and practical conference with international participation; 2012 Oct 3–5; Moscow, Russia. Moscow; 2012. P. 596–602. (In Russ).
- Markova EYu, Kurenkova NV, Matveev AV, et al. Computer visual syndrome in children and adolescents. Nevsky Horizons-2012: materials of a scientific conference of ophthalmologists; 2012 Oct 12–13; St. Petersburg, Russia. St. Petersburg; 2012. P. 217–218. (In Russ).
- Vorontsova OA, Brzhesky VV. Features of clinical course of dry eye syndrome in children. Russian Ophthalmology of Children. 2013;(2):10–17. (In Russ).
- Prozornaya LP. Inflammatory diseases of the ciliary edges of the eyelids. In: Somov EE, editor. Selected sections of pediatric clinical ophthalmology. St. Petersburg: Chelovek; 2016. P. 129–137. (In Russ).
- Brzhesky VV. «Dry eye» syndrome in children. In: Somov EE, editor. Selected sections of pediatric clinical ophthalmology. St. Petersburg: Chelovek; 2016. P. 165–189. (In Russ).
- Kovaleva LA, Kuznetsova TV, Baisangurova AA, Zaitseva AA. Clinical features, diagnosis, and treatment of dry eye syndrome in children. Russian Pediatric Ophthalmology. 2023;18(2):95–104. (In Russ). doi: 10.17816/rpoj321832
- Brzheskiy VV. «Dry eye» syndrome in the children: current possibilities for diagnostics and treatment (the guidelines for practitioners). Russian Pediatric Ophthalmology. 2017;12(2):73–81. (In Russ). doi: 10.18821/1993-1859-2017-12-2-73-81
- Ponomareva MN, Verbina AV, Andrievskikh OA. Early diagnosis of the syndrome of the dry eye in rheumatoid arthritis. Point of view. East-West. 2017;(3):121–124. (In Russ).
- Brzheskaya IV, Brzhesky VV, Radhuan M. Current trends in the therapy of the ocular surface epithelial xerosis. Ophthalmology reports. 2014;7(3):45–56. (In Russ).
- Prozornaya LP, Brzheskiy VV. Сomparative effect of artificial tear drug usage in patients with «dry eye» syndrome and chronic blepharitis. Pediatrician (St. Petersburg). 2013;4(1):53–57. (In Russ).
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