One-Carbon Metabolism Disorders in Schizophrenia: Genetic and Therapeutic Aspects


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We review the role of disorders of one-carbon metabolism (OCM) in the etiopathogenesis of schizophrenia, define directions for further research into the role of single nucleotide genetic polymorphisms of the folate pathway enzymes, and outlined future lines of studies on personalized correction of OCM disorders. The reviewed data suggest that it is necessary to perform complex studies on the genetic risk of OCM disorders, molecular mechanisms of schizophrenia pathogenesis, which involve OCM disorders, and the clinical effects of their personalized correction.

作者简介

T. Zhilyaeva

Volga Research Medical University

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Email: bizet@inbox.ru
俄罗斯联邦, pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005

A. Sergeeva

Volga Research Medical University

Email: bizet@inbox.ru
俄罗斯联邦, pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005

A. Blagonravova

Volga Research Medical University

Email: bizet@inbox.ru
俄罗斯联邦, pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005

G. Mazo

Bekhterev National Medical Research Center for Psychiatry and Neurology

Email: bizet@inbox.ru
俄罗斯联邦, St. Petersburg

A. Kibitov

Serbskii National Medical Center for Psychiatry and Narcology

Email: bizet@inbox.ru
俄罗斯联邦, Moscow

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