Email this article One-Carbon Metabolism Disorders in Schizophrenia: Genetic and Therapeutic Aspects
- Authors: Zhilyaeva T.V.1, Sergeeva A.V.1, Blagonravova A.S.1, Mazo G.E.2, Kibitov A.O.3
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Affiliations:
- Volga Research Medical University
- Bekhterev National Medical Research Center for Psychiatry and Neurology
- Serbskii National Medical Center for Psychiatry and Narcology
- Issue: Vol 13, No 2 (2019)
- Pages: 113-120
- Section: Review Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211699
- DOI: https://doi.org/10.1134/S1819712419020156
- ID: 211699
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Abstract
We review the role of disorders of one-carbon metabolism (OCM) in the etiopathogenesis of schizophrenia, define directions for further research into the role of single nucleotide genetic polymorphisms of the folate pathway enzymes, and outlined future lines of studies on personalized correction of OCM disorders. The reviewed data suggest that it is necessary to perform complex studies on the genetic risk of OCM disorders, molecular mechanisms of schizophrenia pathogenesis, which involve OCM disorders, and the clinical effects of their personalized correction.
About the authors
T. V. Zhilyaeva
Volga Research Medical University
Author for correspondence.
Email: bizet@inbox.ru
Russian Federation, pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005
A. V. Sergeeva
Volga Research Medical University
Email: bizet@inbox.ru
Russian Federation, pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005
A. S. Blagonravova
Volga Research Medical University
Email: bizet@inbox.ru
Russian Federation, pl. Minina i Pozharskogo 10/1, Nizhny Novgorod, 603005
G. E. Mazo
Bekhterev National Medical Research Center for Psychiatry and Neurology
Email: bizet@inbox.ru
Russian Federation, St. Petersburg
A. O. Kibitov
Serbskii National Medical Center for Psychiatry and Narcology
Email: bizet@inbox.ru
Russian Federation, Moscow
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