Email this article Exosome Drug Delivery through the Blood–Brain Barrier: Experimental Approaches and Potential Applications
- Authors: Druzhkova T.A.1, Yakovlev A.A.1,2,3
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Affiliations:
- Solov’ev Scientific and Practical Psychoneurological Center
- Institute of Higher Nervous Activity and Neurophysiology
- Aff3
- Issue: Vol 12, No 3 (2018)
- Pages: 195-204
- Section: Review Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211517
- DOI: https://doi.org/10.1134/S1819712418030030
- ID: 211517
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Abstract
This review discusses the current experimental data on targeted drug delivery through the blood–brain barrier (BBB). We focus on exosome drug delivery and examine the unique biological structure of exosomes, which allows them to pack, store, and deliver various molecules to the brain. Various approaches to modification and engineering of exosomes are reviewed with an analysis of experimental studies of exosome drug delivery through the BBB. The problems associated with potential clinical uses of exosomes and their possible solutions are discussed.
About the authors
T. A. Druzhkova
Solov’ev Scientific and Practical Psychoneurological Center
Email: al_yakovlev@rambler.ru
Russian Federation, Moscow
A. A. Yakovlev
Solov’ev Scientific and Practical Psychoneurological Center; Institute of Higher Nervous Activity and Neurophysiology; Aff3
Author for correspondence.
Email: al_yakovlev@rambler.ru
Russian Federation, Moscow; Moscow; ul. Butlerova, 5a, Moscow, 117485
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