The Effects of Cortexin on Free-Radical Oxidation and Inflammatory Processes in Rats with Normal and Accelerated Aging
- Authors: Stepanichev M.Y.1, Onufriev M.V.1, Peregud D.I.1, Lazareva N.A.1, Moiseeva Y.V.1, Nesterenko A.N.1, Novikova M.R.1, Stefanova N.A.2, Kolosova N.G.2, Gulyaeva N.V.1
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Affiliations:
- Institute of Higher Nervous Activity and Neurophysiology
- Institute of Cytology and Genetics, Siberian Branch
- Issue: Vol 12, No 2 (2018)
- Pages: 184-194
- Section: Experimental Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211512
- DOI: https://doi.org/10.1134/S1819712418020113
- ID: 211512
Cite item
Abstract
We studied the geroprotective properties of Cortexin and the systems of free-radical oxidation and inflammatory processes as potential targets of this drug. The study used 12-month-old male Wistar and OXYS rats with normal and accelerated aging, respectively. After preliminary assessment of their behavior in the open-field test, the rats were divided into homogenous groups according to behavioral indices. The animals were intraperitoneally injected with Cortexin (Geropharm, Russia) at a dose of 1 mg/kg daily for 30 days. The course of treatment with Cortexin did not substantially affect the general conditions and behavioral indices of both Wistar and OXYS rats and had a moderate positive effect on cognitive functions. Cortexin corrected the state of the systems of free-radical oxidation and cytokines. Specifically, in the brains of OXYS rats, Cortexin restored the ratio of the pro- and antioxidant systems primarily in the neocortex; however, a systemic effect was also observed. A significant anti-inflammatory effect was found at the systemic level and in the brain.
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About the authors
M. Yu. Stepanichev
Institute of Higher Nervous Activity and Neurophysiology
Author for correspondence.
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
M. V. Onufriev
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
D. I. Peregud
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
N. A. Lazareva
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
Yu. V. Moiseeva
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
A. N. Nesterenko
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
M. R. Novikova
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
N. A. Stefanova
Institute of Cytology and Genetics, Siberian Branch
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Novosibirsk
N. G. Kolosova
Institute of Cytology and Genetics, Siberian Branch
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Novosibirsk
N. V. Gulyaeva
Institute of Higher Nervous Activity and Neurophysiology
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow
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