The Effects of Cortexin on Free-Radical Oxidation and Inflammatory Processes in Rats with Normal and Accelerated Aging


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Abstract

We studied the geroprotective properties of Cortexin and the systems of free-radical oxidation and inflammatory processes as potential targets of this drug. The study used 12-month-old male Wistar and OXYS rats with normal and accelerated aging, respectively. After preliminary assessment of their behavior in the open-field test, the rats were divided into homogenous groups according to behavioral indices. The animals were intraperitoneally injected with Cortexin (Geropharm, Russia) at a dose of 1 mg/kg daily for 30 days. The course of treatment with Cortexin did not substantially affect the general conditions and behavioral indices of both Wistar and OXYS rats and had a moderate positive effect on cognitive functions. Cortexin corrected the state of the systems of free-radical oxidation and cytokines. Specifically, in the brains of OXYS rats, Cortexin restored the ratio of the pro- and antioxidant systems primarily in the neocortex; however, a systemic effect was also observed. A significant anti-inflammatory effect was found at the systemic level and in the brain.

About the authors

M. Yu. Stepanichev

Institute of Higher Nervous Activity and Neurophysiology

Author for correspondence.
Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

M. V. Onufriev

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

D. I. Peregud

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

N. A. Lazareva

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

Yu. V. Moiseeva

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

A. N. Nesterenko

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

M. R. Novikova

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

N. A. Stefanova

Institute of Cytology and Genetics, Siberian Branch

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Novosibirsk

N. G. Kolosova

Institute of Cytology and Genetics, Siberian Branch

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Novosibirsk

N. V. Gulyaeva

Institute of Higher Nervous Activity and Neurophysiology

Email: mikhail_stepanichev@yahoo.com
Russian Federation, Moscow

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