The influence of the long-term emotional pain stress on the methylation of histone H3 in the cells of the hippocampus and amygdala of rats with different excitability of the nervous system
- Авторы: Pavlova M.B.1, Shiryaeva N.V.1, Dyuzhikova N.A.1, Vaido A.I.1
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Учреждения:
- Pavlov Institute of Physiology
- Выпуск: Том 11, № 3 (2017)
- Страницы: 229-235
- Раздел: Experimental Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211290
- DOI: https://doi.org/10.1134/S1819712417030096
- ID: 211290
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Аннотация
We performed an immunohistochemical study of histone H3 methylation at lysine 4 (H3K4medi+ tri) in the neurons of the hippocampus (CA3 area) and basolateral amygdala in rats with different levels of nervous system excitability under normal conditions and at different time points (24 hours, 2 weeks, and 2 months) after long-term emotional pain stress (LEPS). We found higher immunoreactivity of cells in both brain structures under normal conditions in the control groups of low-excitability rats of the HT strain in comparison with high-excitability rats of the LT strain. We describe the structural and temporal patterns of the influence of long-term emotional pain stress on the level of histone H3 methylation (K4), which depend on the excitability of the nervous system of the examined strains.
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M. Pavlova
Pavlov Institute of Physiology
Автор, ответственный за переписку.
Email: marina.absp@mail.ru
Россия, nab. Makarova 6, St. Petersburg, 199034
N. Shiryaeva
Pavlov Institute of Physiology
Email: marina.absp@mail.ru
Россия, nab. Makarova 6, St. Petersburg, 199034
N. Dyuzhikova
Pavlov Institute of Physiology
Email: marina.absp@mail.ru
Россия, nab. Makarova 6, St. Petersburg, 199034
A. Vaido
Pavlov Institute of Physiology
Email: marina.absp@mail.ru
Россия, nab. Makarova 6, St. Petersburg, 199034
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