The effects of high-energy protons and carbon ions (12C) on the cognitive function and the content of monoamines and their metabolites in peripheral blood in monkeys
- Authors: Belyaeva A.G.1, Shtemberg A.S.1,2, Nosovskii A.M.1, Vasil’eva O.N.1, Gordeev Y.V.1, Kudrin V.S.1,3, Narkevich V.B.3, Krasavin E.A.2, Timoshenko G.N.2, Lapin B.A.4, Bazyan A.S.1,5,2,6
-
Affiliations:
- State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems
- Joint Institute for Nuclear Research
- Zakusov Institute of Pharmacology
- Research Institute for Medical Primatology
- Institute for Higher Nervous Function and Neurophysiology
- Aff6
- Issue: Vol 11, No 2 (2017)
- Pages: 168-175
- Section: Experimental Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211263
- DOI: https://doi.org/10.1134/S1819712417010032
- ID: 211263
Cite item
Abstract
Model experiments using monkeys (rhesus macaque monkeys) were performed to investigate the neurobiological effects of two components of galactic cosmic radiation, namely, high-energy protons and carbon (12C) ions. It has been demonstrated that the irradiation of a monkey’s head with protons at a dose of 3 Gy did not cause any significant changes in the animal’s cognitive function and in the concentrations of monoamines and their metabolites in the peripheral blood. However, exposure to carbon ions at a dose of 1 Gy resulted in a significant cognitive function impairment and a significant decrease in serotonin metabolite concentrations in the blood in the monkeys with the excitable imbalanced type of higher nervous activity.
Keywords
About the authors
A. G. Belyaeva
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems
Email: bazyan@mail.ru
Russian Federation, Moscow
A. S. Shtemberg
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems; Joint Institute for Nuclear Research
Email: bazyan@mail.ru
Russian Federation, Moscow; Dubna, Moscow Region
A. M. Nosovskii
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems
Email: bazyan@mail.ru
Russian Federation, Moscow
O. N. Vasil’eva
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems
Email: bazyan@mail.ru
Russian Federation, Moscow
Yu. V. Gordeev
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems
Email: bazyan@mail.ru
Russian Federation, Moscow
V. S. Kudrin
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems; Zakusov Institute of Pharmacology
Email: bazyan@mail.ru
Russian Federation, Moscow; Moscow
V. B. Narkevich
Zakusov Institute of Pharmacology
Email: bazyan@mail.ru
Russian Federation, Moscow
E. A. Krasavin
Joint Institute for Nuclear Research
Email: bazyan@mail.ru
Russian Federation, Dubna, Moscow Region
G. N. Timoshenko
Joint Institute for Nuclear Research
Email: bazyan@mail.ru
Russian Federation, Dubna, Moscow Region
B. A. Lapin
Research Institute for Medical Primatology
Email: bazyan@mail.ru
Russian Federation, Sochi
A. S. Bazyan
State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems; Institute for Higher Nervous Function and Neurophysiology; Joint Institute for Nuclear Research; Aff6
Author for correspondence.
Email: bazyan@mail.ru
Russian Federation, Moscow; Moscow; Dubna, Moscow Region; ul. Butlerova 5a, Moscow, 117485
Supplementary files
