The effects of high-energy protons and carbon ions (12C) on the cognitive function and the content of monoamines and their metabolites in peripheral blood in monkeys


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Abstract

Model experiments using monkeys (rhesus macaque monkeys) were performed to investigate the neurobiological effects of two components of galactic cosmic radiation, namely, high-energy protons and carbon (12C) ions. It has been demonstrated that the irradiation of a monkey’s head with protons at a dose of 3 Gy did not cause any significant changes in the animal’s cognitive function and in the concentrations of monoamines and their metabolites in the peripheral blood. However, exposure to carbon ions at a dose of 1 Gy resulted in a significant cognitive function impairment and a significant decrease in serotonin metabolite concentrations in the blood in the monkeys with the excitable imbalanced type of higher nervous activity.

About the authors

A. G. Belyaeva

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems

Email: bazyan@mail.ru
Russian Federation, Moscow

A. S. Shtemberg

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems; Joint Institute for Nuclear Research

Email: bazyan@mail.ru
Russian Federation, Moscow; Dubna, Moscow Region

A. M. Nosovskii

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems

Email: bazyan@mail.ru
Russian Federation, Moscow

O. N. Vasil’eva

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems

Email: bazyan@mail.ru
Russian Federation, Moscow

Yu. V. Gordeev

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems

Email: bazyan@mail.ru
Russian Federation, Moscow

V. S. Kudrin

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems; Zakusov Institute of Pharmacology

Email: bazyan@mail.ru
Russian Federation, Moscow; Moscow

V. B. Narkevich

Zakusov Institute of Pharmacology

Email: bazyan@mail.ru
Russian Federation, Moscow

E. A. Krasavin

Joint Institute for Nuclear Research

Email: bazyan@mail.ru
Russian Federation, Dubna, Moscow Region

G. N. Timoshenko

Joint Institute for Nuclear Research

Email: bazyan@mail.ru
Russian Federation, Dubna, Moscow Region

B. A. Lapin

Research Institute for Medical Primatology

Email: bazyan@mail.ru
Russian Federation, Sochi

A. S. Bazyan

State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems; Institute for Higher Nervous Function and Neurophysiology; Joint Institute for Nuclear Research; Aff6

Author for correspondence.
Email: bazyan@mail.ru
Russian Federation, Moscow; Moscow; Dubna, Moscow Region; ul. Butlerova 5a, Moscow, 117485

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