Copper ions potentiate a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons during glucose deprivation
- Авторы: Genrikhs E.E.1, Stelmashook E.V.1, Turovetskii V.B.2, Khaspekov L.G.1, Isaev N.K.1,2,3,4
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Учреждения:
- Research Center of Neurology
- Department of Biology
- Belozersky Research Institute for Physico-Chemical Biology
- Aff4
- Выпуск: Том 11, № 2 (2017)
- Страницы: 157-160
- Раздел: Experimental Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211255
- DOI: https://doi.org/10.1134/S1819712417020040
- ID: 211255
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Аннотация
We showed that glucose deprivation for 35 min induces a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons, which was enhanced in the presence of 10 μM copper ions (Cu2+). It was associated with an increase in the free-radical level that was not affected by the noncompetitive antagonist of glutamate NMDA receptors MK-801, which prevents subsequently developing neuronal loss. However, in the presence of glucose, Cu2+ did not affect cell viability. Thus, Cu2+ induced stronger oxidative stress during glucose deprivation than in the presence of glucose, which, in turn, results in mitochondrial damage, glutamate release, glutamate receptor hyperstimulation, and neuronal loss.
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E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
E. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
V. Turovetskii
Department of Biology
Email: isaev@genebee.msu.ru
Россия, Moscow
L. Khaspekov
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
N. Isaev
Research Center of Neurology; Department of Biology; Belozersky Research Institute for Physico-Chemical Biology; Aff4
Автор, ответственный за переписку.
Email: isaev@genebee.msu.ru
Россия, Moscow; Moscow; Moscow; Leninskie gory 1 str. 40, Moscow, 119992
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