Age-related changes in the number of microglial cells, lipid peroxidation, and oxidative protein-modification products in the human cerebrum at early stages of ontogenesis

Abstract

The age-related dynamics of the number of microglial cells and the concentration of products of lipid peroxidation (LPO) and oxidative modification of protein (OMP) in areas 6 and 17 of the cerebral cortex and the head of the caudate nucleus were studied. The results of the study showed a continuous increase in the density of microglia in the human forebrain structures at the stage of postnatal ontogenesis. The agerelated increase in the density of microglial cells in the neocortex was accompanied by a simultaneous decrease in the concentrations of lipid peroxidation products and an increase in the level of OMP products. In the caudate nucleus, the age-related increase in the amount of microglia was accompanied by an increase in the concentration of products of lipid peroxidation and OMP.