Molecular markers of the development of posttraumatic stress disorder

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Introduction. Posttraumatic stress disorder (PTSD) is presented as a systemic multilevel metabolic-immuno-psycho-neurological disorder with genetic predisposition and epigenetic influences, which radically changes the approach to its understanding and treatment, taking it far beyond the framework of traditional psychiatry.

Objective: Identification of molecular pathogenesis pathways holds promise for targeted management of aggressive and impulsive behaviors in PTSD. The purpose of this review is to analyze current data on the determination of molecular markers that are promising for the diagnosis of PTSD mechanisms of development.

Material and methods. In preparing the review, sources from international (Scopus, Web of Science, PubMed) and eLIBRARY.ru databases for the period 2015–2025 were used.

Results. The key problem of PTSD is discussed – dysfunction in neural networks that process memory, emotional regulation and are interconnected with neurotransmission. The key role of molecular changes in neurons and astrocytes in the development of neuroinflammation in the cortex and limbic system has been demonstrated. The relationship between glymphatic system dysfunction, impaired metabolite clearance, neuroinflammation and neurodegeneration is emphasized.

Conclusion. Identifying specific molecular biomarkers of PTSD sets the stage for developing accurate prognostic tools, facilitating molecular diagnosis, and ideally tailoring personalized therapies effective for each patient’s unique clinical phenotype.

作者简介

Maria Kolpakova

Federal State Budgetary Scientific Institution I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: kolpakovame@infran.ru
ORCID iD: 0000-0003-3013-5582

PhD in Physiology Sciences, Associate Professor, Senior Researcher at the Laboratory of Cardiovascular and Lymphatic Systems

俄罗斯联邦, Makarova emb., 6, Saint-Petersburg, 199034

Sergey Pyanzin

O-TRI Medical Center

编辑信件的主要联系方式.
Email: pyanzin@inbox.ru
ORCID iD: 0009-0001-3835-6665

PhD in Neurology Sciences, Chief Medical Officer

俄罗斯联邦, Shpalernaya str., 34, Saint-Petersburg, 191123

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