Matrix metalloproteinase polymorphisms as predictors of osteoarthritis

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Abstract

This review was conducted to systematize data on the association of matrix proteinase gene polymorphisms (MMP, ADAMTS, ADAM) with the risk of developing osteoarthritis.

Material and methods. A systematic literature search of PubMed and Web of Science databases for the period 2003–2024.

Results. Significant ethnic and population heterogeneity in the distribution of genetic associations was revealed. The most compelling data were obtained for ADAMTS-5 (rs2830585, rs2249350) and ADAMTS-14 (rs4747096) gene polymorphisms, demonstrating reproducible associations across various populations. However, for many other candidate genes (ADAMTS-7, -12, MMP-1, -3, -13), conflicting results are observed, due to both methodological limitations of the studies and true population differences.

Conclusion. The obtained data highlight the complex polygenic nature of hereditary predisposition to osteoarthritis and the need to integrate genetic data with functional studies to establish causal relationships.

About the authors

Anastasia N. Voronova

The Federal State Budgetary Educational Institution of Higher Education “Pacific State Medical University” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: voronova.an@tgmu.ru
ORCID iD: 0000-0001-7571-0750

Candidate of Biological Sciences, Leading Researcher, Interdisciplinary Research Center

Russian Federation, Ostryakov Ave., 2, Vladivostok, 690002

Natalya G. Plekhova

The Federal State Budgetary Educational Institution of Higher Education “Pacific State Medical University” of the Ministry of Health of the Russian Federation

Email: pl_nat@hotmail.com
ORCID iD: 0000-0002-8701-7213

Doctor of Biological Sciences, Professor of the Department of Clinical Laboratory Diagnostics, General and Clinical Immunology, Head of the Interdisciplinary Research Center

Russian Federation, Ostryakov Ave., 2, Vladivostok, 690002

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