Proliferotropic effect of combinations of short peptides and encoded amino acids in organotypic tissue culture of various origins
- Authors: Chalisova N.I.1,2, Ivanova P.N.1, Egozova E.S.3
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Affiliations:
- Institute of Physiology named after I.P. Pavlova RAS
- St. Petersburg Institute of Bioregulation and Gerontology
- Russian State Pedagogical University named after. A.I. Herzen
- Issue: Vol 21, No 5 (2023)
- Pages: 47-51
- Section: Original research
- URL: https://ogarev-online.ru/1728-2918/article/view/146571
- DOI: https://doi.org/10.29296/24999490-2023-05-07
- ID: 146571
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Abstract
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body.
Purpose of the study. The purpose of this study was to identify the effect of combinations of encoded amino acids and short peptides in organotypic tissue culture of various genesis of young (3-month-old) and old (18-month-old) rats.
Method. The method of organotypic cultivation of tissues of mesodermal origin (cartilage, kidney, testes) and ectodermal origin (pancreas) of rats was used for rapid screening of the biological activity of the studied substances.
Results. It has been established that the combined use of amino acids and short peptides enhances their proliferative effect, which leads to a potentiating effect of the drugs used.
Conclusion. The data obtained create the basis for the targeted development of new drugs, including geroprotective ones, for the treatment of pathologies of the nervous and immune systems.
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##article.viewOnOriginalSite##About the authors
Natalia I. Chalisova
Institute of Physiology named after I.P. Pavlova RAS; St. Petersburg Institute of Bioregulation and Gerontology
Author for correspondence.
Email: ni_chalisova@mail.ru
ORCID iD: 0000-0002-2371-0043
Expert Scientific Worker of the I.P. Pavlov Institute of Physiology RAS; Expert Scientific Worker of the Laboratory of Oncogerontology of Biogerontology Department of Saint Petersburg Institute of Bioregulation and Gerontology, Doctor of Biologic Sciences, Professor
Russian Federation, emb. Makarova, 6, St. Petersburg, 199034; Dynamo Ave., 3, St. Petersburg, 197110Polina N. Ivanova
Institute of Physiology named after I.P. Pavlova RAS
Email: ivanovapolina19@mail.ru
ORCID iD: 0000-0001-7112-0673
Scientific Worker of Petersburg Institute of Bioregulation and Gerontology
Russian Federation, emb. Makarova, 6, St. Petersburg, 199034Ekaterina S. Egozova
Russian State Pedagogical University named after. A.I. Herzen
Email: ekaterina_egozova@mail.ru
ORCID iD: 0000-0002-0055-3778
Magister
Russian Federation, emb. R. Moiki, 48, St. Petersburg, 191186References
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