BIOLOGY OF THE ORAL CAVITY IN CHILDREN LIVING IN THE CITY OF CHIRCHIK

The study of microbiological and immunological parameters of the oral cavity among children living in the industrial city of Chirchik, the total number of anaerobes, aerobes, phagocytic activity of neutrophils, the level of lysozyme and the immunoglobulin A secretion fraction of the secretory fraction (sIgA) has been studied. To address this goal, we conducted microbiological and immunological studies in 57 children living in the town of Chirchik. All these children, depending on their age, were divided into 3 groups: Group 1 included 17 children aged 6-7 years. Group 2 consisted of 25 children aged 8-12 years. The third group consisted of 15 children aged 13-15. In children aged 6-7 years, it can be noted that the total number of the optional group of microbes is higher than in anaerobic. In this case, the quantitative indicators of the lactobacillus are especially affected among the anaerobes, so their number is Lg. 2.10 ± 0.1 cfu /ml. Alarming in this group of children is the sowing of pathogenic strains of staphylococcus. The remaining groups of microbes, although there are minor changes, but they are unreliable. At children in the age of 2 and 3 group the flora of the oral cavity in many respects stands close to normal indices. Although it should be noted a significant increase in the number of streptococci, especially strains of Str. mutans and mitis. In children in the age group 6-7 years, almost all indicators show immunodeficiency, so the lysozyme titer was 14 ± 0.41 mg /%, it was normally 19.180 ± 0.60 mg/%, the index of phagocytosis was 48.4 ± 1.45% significantly lower than the control indices, the level of secretory immunoglobulin of class A (sIgA) was 1.7 ± 0.1 g/l, which is much lower than normal values. It is interesting to note that in children older than 8-12 and 13-15 years, these indicators have improved significantly, although it should be noted that their immunodeficiency has worsened, only in terms of the fraction of secretory immunoglobulin A (sIgA). From the above, it follows: 1. According to the sanitary and hygienic and microbiological studies carried out, it is possible to state that the city of Chirchik is an ecologically unfavorable region. 2. The study of oral micro-ecology in children in Chirchik made it possible to establish that in children in the age group 6-7 years the most pronounced are dysbiotic conditions, the main feature of which is the decrease in the amount of lactobacillus, but the increase in the number of staphylococci and fungi of the genus Candida 3. When studying the local factors of oral protection in children living in Chirchik in the age aspect, it was found that immunodeficiency states are most pronounced in children of the I group. 4. The study of the state of colonization resistance of microbes in children living in the city of Chirchik established that the most pronounced violations in these issues were noted in the children of group I.

anaerobes, aerobes, phagocytosis, secretory immunoglobulin A (sIgA), children, Str.mutans and mitis, lactobacilli, indices