PECULIARITY OF IMMUNOLOGICAL ACTIVITY OF PERIPHERAL BLOOD IN PERSONS OF DIFFERENT AGE GROUPS IN POLAR REGIONS

Immunological reactivity of northerners is characterized by elevated levels immunosuppression. As a result of ineffectiveness of the suppressor unit onset and growth of CEC concentrations, some immunoglobulins and autoantibodies took place. The physiological importance of human's cell-mediated cytotoxicity is defined in the reactions of immune homeostasis, not only in pathology and vaccination, but in the period of adaptation to changing environmental conditions among residents living in extreme climatic and ecological conditions, special living conditions, particularly in the Polar region. Cell-mediated cytotoxicity provides homeostasis of activation and suppression processes of immune responses in surveyed depending on the concentration ratio of cell activator (CD71+, HLA-DR+), differentiated CD3+ and cytotoxic cells (CD8+, CD16+), age, and professional life conditions. All abovementioned has identified the necessity to assess the physiological role of cytotoxic cells in the mechanism of immune response in healthy persons in the European North of Russia. The results and their comparison with the few published data allow to conside that the cytotoxic lymphocytes (CD8+, CD16+) determine cell-mediated cytotoxic activity in the immune homeostasis in individuals of polar regions.

North, immune status, cytotoxic lymphocytes, natural killer cells, T-helper cells