CORRELATION OF THE SHEDDING OF LYMPHOCYTES RECEPTORS WITH PARAMETERS OF IMMUNOLOGIC REACTIVITY IN RESIDENTS OF THE NORTH

The study retrospectively investigated correlation characteristics of membrane and soluble forms of lymphocyte receptors in 78 healthy people living in the city of Arkhangelsk. The results of a statistical analysis allowed to evaluate the relationship of dynamic indices of shedding lymphocyte receptors CD23 and CD80 to the immunological reactivity indices. It was found that the receptors' shedding was not associated with the processes of proliferation and activation of immune cells, and the receptors abscission occurred by postmitotic mature cells. A high ratio reflecting the relationship of shedding activity of membrane forms of lymphocyte with cytokine IL-1 and IL-10 in the extracellular medium was a reflection of the biological processes regulating the in the form of feedback: increasing of receptor concentration in the extracellular medium by means of cytokine blocked cell receptor expression. Low values of the analyzed indices for CD95 receptor indicated that the cells got free from unnecessary receptor substances in the course of performing its function did not undergo apoptosis. Accumulation of receptors extracellular pool was provided by phagocytosis deficiency. Increase of phagocytosis intensity at a maximum concentration of free receptors was due to the necessity of urgent prevention of unwanted substances accumulation in the blood serum.

CD23, CD80, shedding of lymphocyte receptors, CD23, CD80, cytokine, phagocytic activity