EPIGENETIC PANDEMIC OF MENTAL IMMUNE DEFICIENCY: FROM PSYCHIC TRAUMATIZATION OF CHILDHOOD TO CUMULATIVE EXISTENTIAL STRESS

The feature of the modern world is a steady increase in the prevalence of all major mental and psychosomatic disorders. The global predictor of this trend is in many ways the psychic traumatization of childhood and chronic existential stress. They trigger transgenerational and cumulative mechanisms of epigenetic development of the pandemic of mental immune deficiency (PMID). The task of the study is to describe and systematize epigenetic dysfunctions of mental immunity (MI), clinically manifested by the syndrome of mental immune deficiency (SMID) and triggering epidemiological cascade: mental epidemic - destructive mental epidemic - pandemic of mental immune deficiency. Early stress has both acute and long-term effects on epigenetic labels in the brain, which accumulate in MI, affecting cognitive functions and behavior, the risk of suicide and injurious acts or civil wrongdoing, dependent and psychic disorders throughout the life of today's and tomorrow's generations. SMID is clinically represented by a variety of borderline identity disorders. The pathogenetic basis of the SMID is the epigenetic accumulation of functional (reversible and dynamic) disturbances in the MI as the multimodal interface of consciousness and biopsychosociospiritual identity matrix. The MI is in many respects a standard placeholder, denoting the missing or indeterminate parameter in the network of the relationship between identity and behavior genome and epigenome. Functional family diagnostics and screening in mental medicine (MM) make it possible to focus clinical research on the entire accessible generational line: great-grandchildren - grandchildren - children - parents - grandparents - great-grandparents. This makes it possible to assess and predict latent genetic and epigenetic predictors by calculating probabilistic scenarios and trajectories of development of destinies. Our long-term studies of the early psychic traumatization of childhood have shown the multivariance of changes in MI and biopsychosociospiritual characteristics of the "traumatogenic family", depending on the severity and duration of transgenerational stress burden. Methodology of MM allows designing effective integrative programs for protection of public health.

neuroepigenetics, mental medicine, mental immunity, pandemic of mental immune deficiency, early trauma, existential stress, "traumatogenic epigenome", interface of consciousness, identity matrix