Injected bone cements based on magnesium-substituted whitlockite, containing sodium carboxymethyl cellulose

Cover Page

Cite item

Full Text

Abstract

   Research subject. Calcium-magnesium phosphate powder and cement materials and cement fluid containing sodium carboxymethylcellulose (CMC).   Aim. To develop injectable bone cements based on soluble phases of calcium and magnesium phosphates for possible use in minimally invasive surgery.   Methods. Fritsch Analysis 22 laser particle analyser, Shimadzu XRD-6000 diffractometer, Tescan Vega II scanning electron microscope with an Oxford Instruments Inca X-Act energy dispersive analyser, Tristar 3000 particle analyser, Brookfield DV2T viscometer, Instron 5581 and Instron 3382 universal testing machines were used to characterise the materials.   Results. The introduction of CMC resulted in an increase in the viscosity and surface tension of the cement fluid, which resulted in an increase in the injectability and cohesion in aqueous media of the resulting cement materials. The effects of CMC introduction and mechanochemical activation on the phase composition, setting time, microstructure, cohesion, injectability and strength properties of the cement materials were determined.

About the authors

M. A. Goldberg

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

Email: mgoldberg@imet.ac.ru

P. A. Krokhicheva

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

D. R. Khayrutdinova

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

A. S. Fomin

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

A. V. Leonov

M.V. Lomonosov Moscow State University, 1А Lenin Hills

A. S. Baikin

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

O. S. Antonova

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

A. M. Sentsova

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

N. O. Donskaya

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

S. M. Barinov

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

V. S. Komlev

A.A. Baikov Institute of Metallurgy and Materials Science, RAS

References

  1. Barth J.A., Verbeeck R.M.H. (1984) The CaO-MgO-P,O, System Das Ca0-Mg0-P206-8ystem boi 1000°C fur P z O ~
  2. Cahyanto A., Imaniyyah A.G., Zakaria M.N., Hasratiningsih Z. (2017) Mechanical Strength Properties of Injectable Carbonate Apatite Cement with Various Concentration of Sodium Carboxymethyl Cellulose. Key Engin. Mater., 758, 56-60. doi: 10.4028/ href='WWW.SCI-ENTIFIC.NET/KEM.758.56' target='_blank'>WWW.SCI-ENTIFIC.NET/KEM.758.56
  3. Demir-Oğuz Ö., Boccaccini A.R., Loca D. (2023) Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring? Bioactive Mater., 19, 217-236. doi: 10.1016/J.BIOACT-MAT.2022.04.007
  4. Goldberg M.A., Krohicheva P.A., Fomin A.S., Khairutdinova D.R., Antonova O.S., Baikin A.S., Smirnov V.V., Fomina A.A., Leonov A.V., Mikheev I.V., Sergeeva N.S., Akhmedova S.A., Barinov S.M., Komlev V.S. (2020a) Insitu magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations. Bioactive Mater., 5(3), 644-658. doi: 10.1016/j.bioactmat.2020.03.011
  5. Jacquart S., Girod-Fullana S., Brouillet F., Pigasse C., Siadous R., Fatnassi M., Grimoud J., Rey C., Roques C., Combes C. (2022) Injectable bone cement containing carboxymethyl cellulose microparticles as a silver delivery system able to reduce implant-associated infection risk. Acta Biomater., 145, 342-357. doi: 10.1016/J.ACTBIO.2022.04.015
  6. Jacquart S., Poquillon D., Dechambre G., Cazalbou S., Rey C., Combes C. (2016) Mechanical properties of self-setting composites: Influence of the carboxymethylcellulose content and hydration state. J. Mater. Sci., 51(9), 4296-4305. doi: 10.1007/s10853-016-9739-4
  7. Kobayashi H., Fujishiro T., Belkoff S.M., Kobayashi N., Turner A.S., Seim H.B., Zitelli J., Hawkins M., Bauer T.W. (2009) Long-term evaluation of a calcium phosphate bone cement with carboxymethyl cellulose in a vertebral defect model. J. Biomed. Mater. Res. Part A, 88A(4), 880-888. doi: 10.1002/jbm.a.31933
  8. Krokhicheva P.A., Goldberg M.A., Fomin A.S., Khayrutdinova D.R., Antonova O.S., Baikin A.S., Konovalov A.A., Leonov A.V., Mikheev I.V., Merzlyak E.M., Kirsanova V.A., Sviridova I.K., Sergeeva N.S., Barinov S.M., Komlev V.S. (2023) Enhanced bone repair by silver-doped magnesium calcium phosphate bone cements. Ceramics Int. doi: 10.1016/j.ceramint.2023.03.052
  9. Lee H.J., Kim B., Padalhin A R., Lee B.T. (2019) Incorporation of chitosan-alginate complex into injectable calcium phosphate cement system as a bone graft material. Mater. Sci. Engin. C, 94, 385-392. doi: 10.1016/j.msec.2018.09.039
  10. Li C., Hao W., Wu C., Li W., Tao J., Ai F., Xin H., Wang X. (2020) Injectable and bioactive bone cement with moderate setting time and temperature using borosilicate bio-glass-incorporated magnesium phosphate. Biomed. Mater., 15(4), 045015. doi: 10.1088/1748-605X/AB633F
  11. Liu W.C., Wang H.Y., Chen L.C., Huang S.W., Wu C., Chung R.J. (2019) Hydroxyapatite/tricalcium silicate composites cement derived from novel two-step sol-gel process with good biocompatibility and applications as bone cement and potential coating materials. Ceramics Int., 45(5), 5668-5679. doi: 10.1016/j.ceramint.2018.12.032
  12. Miehle E., Bader-Mittermaier S., Schweiggert-Weisz U., Hauner H., Eisner P. (2021) Effect of physicochemical properties of carboxymethyl cellulose on diffusion of glucose. Nutrients, 13(5). doi: 10.3390/nu13051398
  13. Rahman M.S., Hasan M.S., Nitai A.S., Nam S., Karmakar A.K., Ahsan M.S., Shiddiky M.J.A., Ahmed M.B. (2021) Recent developments of carboxymethyl cellulose. Polymers, 13(8), 1345. doi: 10.3390/POLYM13081345/S1
  14. Shelekhov E.V, Sviridova T.A. (2000) PROGRAMS FOR X-RAY ANALYSIS OF POLYCRYSTALS. Temlicheskaya Obrabotka Metallov, 42(8).
  15. Wang Q., Dong, J. F., Fang, X., & Chen, Y. (2022). Application and modification of bone cement in vertebroplasty : A literature review. Joint Diseases and Related Surgery, 33(2), 467-478. doi: 10.52312/jdrs.2022.628
  16. Wang, X.H., Jia S.J., Hao D.J., Wang N.N. (2020) Advances in the modification of injectable calcium-phosphate-based bone cements for clinical application. Chin. Med. J., 133(21), 2610-2612. doi: 10.1097/CM9.0000000000001092
  17. Wei J., Jia J., Wu F., Wei S., Zhou H., Zhang H., Shin J.W., Liu C. (2010) Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration. Biomaterials, 31(6), 1260-1269. doi: 10.1016/j.biomaterials.2009.11.005
  18. Wei L., Chen C., Hou Z., Wei H. (2016) Poly (acrylic acid sodium) grafted carboxymethyl cellulose as a high performance polymer binder for silicon anode in lithium ion batteries. Sci. Rep., 6. doi: 10.1038/srep19583
  19. Wu F., Su J., Wei J., Guo H., Liu C. (2008) Injectable bioactive calcium-magnesium phosphate cement for bone regeneration. Biomed. Mater., 3(4). doi: 10.1088/1748-6041/3/4/044105

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Goldberg M.A., Krokhicheva P.A., Khayrutdinova D.R., Fomin A.S., Leonov A.V., Baikin A.S., Antonova O.S., Sentsova A.M., Donskaya N.O., Barinov S.M., Komlev V.S.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).