Email this article The use of microneedling and laser therapy in patients with involutive skin changes
- Authors: Kruglova L.S.1, Avagumyan M.A.1, Tamrazova A.V.1
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Affiliations:
- Central State Medical Academy of the Presidential Administration of the Russian Federation
- Issue: Vol 20, No 5 (2021)
- Pages: 397-404
- Section: Original studies
- URL: https://ogarev-online.ru/1681-3456/article/view/107862
- DOI: https://doi.org/10.17816/rjpbr107862
- ID: 107862
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Abstract
BACKGROUND: Involutive skin changes are an urgent problem in the modern world, which leads to the need to find a comprehensive and effective treatment method aimed at reducing the activity of matrix metalloproteinases (MMPs) and transforming growth factor-β2 (TGF-β2), which are responsible for the degradation of extracellular matrix proteins.
AIMS: Determination of the degree of influence of microneedling monotherapy, fractional laser, as well as a combination of these methods on the content of MMP-2, MMP-3, MMP-12, TGF-β2 in the skin of patients with involutive signs.
MATERIAL AND METHODS: In a single-center, prospective, parallel, non-randomized study, 82 patients with involutive changes in the facial skin took part, which were divided into 3 groups. 26 patients (Group 1) received microneedling monotherapy (3 treatments every 3 weeks), 27 patients (Group 2) received fractional laser monotherapy (3 treatments every 4 weeks) and 29 patients (Group 3) combined therapy of microneedling and fractional laser (3 procedures every 4 weeks). The study lasted 10 weeks, before and after the start of the study, a biopsy of the skin behind the ear was taken to determine the level of MMP-2, -3, -12 and TGF-β2.
RESULTS: Comparative data of enzyme immunoassay with biotin monoclonal conjugates between the groups revealed a difference in the content of matrix metalloproteinases and TGF-β: in group 1, there was less significant dynamics in all studied parameters compared to group 3: MMP-2 (p=0.0390), MMP-3 (p=0.0466), MMP-12 (p=0.0104) and TGF-β (p=0.0080) and 2 group MMP-12 (p=0.0484) and TGF-β (p=0.0367). When comparing groups 2 and 3, more significant dynamics was observed in group 3 in terms of MMP-2 (p=0.0290), MMP-12 (p=0.0511) and TGF-β (p=0.0241). Thus, the most significant results were obtained in group 3.
CONCLUSION: Combined treatment using microneedling and fractional laser leads to a significant decrease in the level of MMP-2, -3, -12 and TGF-β2, which allows us to consider this therapeutic complex as a promising way to correct involutive skin changes.
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##article.viewOnOriginalSite##About the authors
Larisa S. Kruglova
Central State Medical Academy of the Presidential Administration of the Russian Federation
Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265
SPIN-code: 1107-4372
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowMariya A. Avagumyan
Central State Medical Academy of the Presidential Administration of the Russian Federation
Email: maruya-kamalova@yandex.ru
ORCID iD: 0000-0003-1898-678X
Russian Federation, Moscow
Anait V. Tamrazova
Central State Medical Academy of the Presidential Administration of the Russian Federation
Author for correspondence.
Email: anaittamrazova@gmail.com
ORCID iD: 0000-0002-4672-697X
Russian Federation, Moscow
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