The development of the composition and technological process for capsules containing (Cichorium intybus L.) herb dried extract

Introduction. Currently, the range of domestic medicines for the treatment of gastrointestinal, liver and kidney diseases is insufficient to meet the needs of the Russian population. Biologically active food supplements, which are widely used by Russians as a substitute for herbal medicines, do not address the issue of preventing and treating this group of conditions.

The aim of this study is to develop a composition and process for producing an oral dosage form – capsules containing a dry extract from the herb Cichorium intybus.

Material and method. The object of the research is the dry extract of chicory (Cichorium intybus L.), obtained from wild plant material. The excipients used in the formulation comply with relevant regulatory standards and are approved for use in medicinal preparations. This research was conducted using the methods outlined in the official standards of the 15^th edition of the State Pharmacopoeia of the Russian Federation.

Results. Based on the study of the physical, chemical, and technological properties of the substance, various compositions of the extract with auxiliary substances were selected. The quality indicators of the extract and capsule mass were determined. Experimental samples were produced by sequentially mixing medicinal and auxiliary substances; pharmaceutical and technological tests were conducted. It was found that the optimal composition has microcrystalline cellulose, lactose monohydrate, and calcium stearate as auxiliary substances.

Conclusions. The composition and process for producing capsules containing a dry extract from the herb, chicory, have been developed. Stability of the capsules during storage over a period of two years and three months was investigated, and the shelf life was determined to be two years.