Antimicrobial activity of aqueous extracts from raw materials, meal and dry extracts of grass and leaves of Chicorium intibus L.
- Авторлар: Babenko А.N.1, Krepkova L.V.1, Fateeva Т.V.1, Saybel О.L.1, Borovkova М.V.1
-
Мекемелер:
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
- Шығарылым: Том 28, № 6 (2025)
- Беттер: 53-60
- Бөлім: Pharmaceutical chemistry
- URL: https://ogarev-online.ru/1560-9596/article/view/310595
- DOI: https://doi.org/10.29296/25877313-2025-06-07
- ID: 310595
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Introdction. Common chicory (Cichorium intybus L.) is a valuable plant containing a sum of biologically active substances with various biological properties. The study of antimicrobial activity of its above-ground part deserves special attention, as it may open new opportunities for the use of this crop both in the diets of farm animals and in the creation of medicinal preparations and functional food additives.
The aim of the work was to study the antimicrobial activity of aqueous extracts from grass and leaves of common chicory and dry extracts and meal obtained from them to determine the possibility of complex use of raw materials of this plant.
Material and methods. The objects of study were raw material, meal and dry extract obtained from grass and leaves of common chicory. Experimental studies were carried out using generally accepted microbiological methods of research with respect to the following strains of pathogenic bacteria: Staphylococcus aureus 6538P, Escherichia coli (ATCC 25922), Proteus vulgaris (ATCC 6896), Pseudomonas aeruginosa (ATCC 9027), mycelial Microsporum canis 352 and yeast-like Candida albicans ATCC 10231) fungi.
Results. Aqueous extracts from grass and leaves of common chicory and their meal had the same bacteriostatic activity against S. aureus 6538 P, E. coli (ATCC 25922), P. vulgaris (ATCC 6896), P. aeruginosa (ATCC 9027). Only aqueous extracts from the raw materials showed fungistatic activity against yeast-like and mycelial fungi; the meal did not possess such properties. Dry extracts had bacteriostatic and fungistatic activity, with the dry extract of chicory herb being 2-4 times more active than the leaf extract of cultivated common chicory.
Conclusions. Common chicory is a valuable and promising plant that can be used as a medicinal plant raw material for the creation of biologically active food additives, as well as feed additives for farm animals.
Негізгі сөздер
Толық мәтін
##article.viewOnOriginalSite##Авторлар туралы
А. Babenko
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Хат алмасуға жауапты Автор.
Email: alexandra.mogileva@gmail.com
ORCID iD: 0000-0001-9629-5525
SPIN-код: 4910-9224
Ph.D. (Biol.), Leading Research Scientist, Toxicology Department
Ресей, 7 Green str., Moscow, 117216L. Krepkova
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: krepkowa2011@yandex.ru
ORCID iD: 0000-0002-3580-336X
SPIN-код: 1394-1808
Ph.D. (Biol.), Head of Toxicology Department
Ресей, 7 Green str., Moscow, 117216Т. Fateeva
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: fateeva2151@mail.ru
ORCID iD: 0000-0002-8231-0621
SPIN-код: 5271-9609
Microbiologist
Ресей, 7 Green str., Moscow, 117216О. Saybel
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: olster@mail.ru
ORCID iD: 0000-0001-8059-5064
SPIN-код: 2842-4587
Dr.Sc. (Pharm.), Head of the Center for Chemistry and Pharmaceutical Technology
Ресей, 7 Green str., Moscow, 117216М. Borovkova
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: borovkova_65@mail.ru
ORCID iD: 0000-0002-3568-6407
SPIN-код: 2682-0970
Senior Research Scientist, Department of Toxicology
Ресей, 7 Green str., Moscow, 117216Әдебиет тізімі
- Street R.A., Sidana J., Prinsloo G. Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology. Evid Based Complement Alternat Med. 2013; 2013: 579319. doi: 10.1155/2013/579319.
- Nwafor I.C., Shale K., Achilonu M.C. Chemical Composition and Nutritive Benefits of Chicory (Cichorium intybus) as an Ideal Complementary and/or Alternative Livestock Feed Supplement. ScientificWorldJournal. 2017; 2017: 7343928. doi: 10.1155/2017/7343928.
- Krepkova L.V., Babenko A.N., Saybel' O.L. et al. Valuable Hepatoprotective Plants – How Can We Optimize Waste Free Uses of Such Highly Versatile Resources? Front Pharmacol. 2021 Nov 18; 12: 738504. DOI: 0.3389/fphar.2021.738504.
- Choudhary S., Kaurav H., Chaudhary G. Kasani beej (Cichorium intybus): Ayurvedic View, Folk View, Phytochemistry and Modern Therapeutic Uses. International Journal for Research in Applied Sciences and Biotechnology. 2021; 8(2). doi: 10.31033/ijrasb.8.2.14.
- Bagno O. A., Prohorov O. N., Shevchenko S. A. i dr. Fitobiotiki v kormlenii sel'skohozjajstvennyh zhivotnyh (obzor). Sel'skohozjajstvennaja biologija. 2018; 4: 687–697. doi: 10.15389/agrobiology.2018.4.687rus (In Russ.).
- Da Silva V.B., Barreira J. C.M., Oliveira, M.B.P. Natural phytochemicals and probiotics as bioactive ingredients for functional foods: Extraction, biochemistry and protected-delivery technologies. Trends in Food Science & Technology, 2016; 50: 144–158. doi: 10.1016/j.tifs.2015.12.007.
- Perović J., Tumbas Šaponjac V., Kojić J. et al. Chicory (Cichorium intybus L.) as a food ingredient – Nutritional composition, bioactivity, safety, and health claims: A review. Food Chem. 2021 Jan 30; 336: 127676. doi: 10.1016/j.foodchem.2020.127676.
- Petrovic J., Stanojkovic A., Comic Lj., Curcic S. Antibacterial activity of Cichorium intybus. Fitoterapia. 2004 Dec; 75(7-8):737–739. doi: 10.1016/j.fitote.2004.05.001.
- Nandagopal S., Ranjitha Kumari B.D. Phytochemical and Antibacterial Studies of Chicory (Cichorium intybus L.) – A Multipurpose Medicinal Plant. Advances in Biological Research. 2007; 1(1-2): 17–21.
- Saxena R., Sulakhiya K. B., Rathore M. Сichorium intybus linn: a review of pharmacological profile. International Journal of Current Pharmaceutical Research. 2014; 6(4): 11–15.
- Al-Snafi A. E. Medical importance of Cichorium intybus – A review. Journal of Pharmacy. 2016; 6(3): 41–56.
- Saeed M., El-Hack M. E. A., Alagawany M. et al. Chicory (Cichorium intybus) herb: Chemical composition, pharmacology, nutritional and healthical applications. International Journal of Pharmacology. 2017; 13(4): 351–360. doi: 10.3923/ijp.2017.351.360.
- Jand K., Gutowska I., Geszke-Moritz M., Jakubczyk K. The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties – A Review. Molecules. 2021: 26: 1814. doi: 10.3390/molecules26061814.
- Boghrati Z., Zibaee E., Ayati Z. et al. Ethnomedicinal Uses, Phytochemistry and Pharmacology of Different Cichorium Species (Asteraceae): A Review. Adv Exp Med Biol. 2021; 1308: 501–546. doi: 10.1007/978-3-030-64872-5_26.
- Upadhayay V.K., Gohar Taj., Pandey D. et al. Contemporary Insights on Antibacterial and Pharmacological Importance of Cichorium intybus: A Compendious Review. Biomed J Sci & Tech. Res. 2021; 35(2).
- Bezerra, M.S., Zeferino, K.S., Menezes, L.D. et al. Antimicrobial and antibiofilm activities of Cichorium intybus: a review. Research, Society and Development. 2022; 11(2): e10911225384. 2022; doi: 10.33448/rsd-v11i2.25384.
- Tahreem R., Muhammad A., Umme L. et al. Phytochemistry and pharmacology of Cichorium intybus. Int. Arch. Integr. Med. 2024; 11(2): 33–46. doi: 10.5281/zenodo.10694047.
- Ivarsson E., Frankow-Lindberg B.E., Andersson H.K. et al. Growth performance, digestibility and faecal coliform bacteria in weaned piglets fed a cereal-based diet including either chicory (Cichorium intybus L.) or ribwort (Plantago lanceolata L.) forage, Animal. 2011; 5(4): 558–564.
- Sajbel' O.L., Radimich A.I., Adamov G.V. i dr. Sravnitel'noe fitohimicheskoe izuchenie nadzemnoj chasti dikorastushhego i kul'tiviruemogo rastenija (Cichorium intybus L.). Himija rastitel'nogo syr'ja. 2020; 3: 187–195. (In Russ.).
- Sajbel' O. L., Radimich A. I., Dargaeva T. D. i dr. Fenol'nye soedinenija i farmakologicheskij skrining jekstrakta travy cikorija obyknovennogo. Razrabotka i registracija lekarstvennyh sredstv. 2021; 10(4): 36–45. doi: 10.33380/2305-2066-2021-10-4-36-45 (In Russ.).
- Kuzina O.S., Borovkova M.V., Babenko A.N. i dr. Vlijanie vozrastnyh izmenenij na toksichnost' jekstrakta suhogo iz travy cikorija obyknovennogo (Cichorium intybus L.). Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2022; 25(8): 53–57. doi: 10.29296/25877313-2022-08-07 (In Russ.).
- Krepkova, L.V., Babenko, A.N., Lemyaseva, S.V., et al. Modulation of Hepatic Functions by Chicory (Cichorium intybus L.) Extract: Preclinical Study in Rats. Pharmaceuticals 2023. 16. 1471. doi: 10.3390/ph16101471.
- Babenko A.N., Krepkova L.V., Lemjaseva S.V., i dr. Gepatoprotektornoe dejstvie cikorija obyknovennogo (Cichorium intubus L.) pri intoksikacii krys sulemoj. Patologicheskaja fiziologija i jeksperimental'naja terapija. 2024; 68(3): 75–84. doi: 10.25557/0031-2991.2024.03.75-84 (In Russ.).
- Babenko A.N., Krepkova L.V., Dmitrieva O.P. i dr. Izuchenie nefroprotektornogo dejstvija suhogo jekstrakta cikorija obyknovennogo (Cichorium intubus L.) pri intoksikacii krys hloridom rtuti (II). Rossijskij zhurnal «Problemy veterinarnoj sanitarii, gigieny i jekologii». 2024;50(2):292 - 299. doi: 10.36871/vet.san.hyg.ecol.202402018 (In Russ.).
- Kuzina O.S., Borovkova M.V., Babenko A.N. Toksichnost' cikorija obyknovennogo (Sichorium intybus L.) kul'tiviruemogo travy suhogo na laboratornyh zhivotnyh raznogo vozrasta. Sbornik nauchnyh trudov, M., FGBNU VILAR. 2021; 585–590. (In Russ.).
- Sajbel' O.L., Dargaeva T.D., Babenko A.N. i dr. Perspektivy primenenija shrota travy i list'ev cikorija obyknovennogo (Sichorium intybus L.) v kormlenii sel'skohozjajstvennyh zhivotnyh. Innovacii i prodovol'stvennaja bezopasnost'. 2022; 38(4): 58–67. doi: 10.31677/2311-0651-2022-38-4-58-67 (In Russ.).
- Babenko A.N., Krepkova L.V. Perspektivy razrabotki lekarstvennogo preparata na osnove cikorija obyknovennogo (Cichorium intybus L.) dlja veterinarii. Dostizhenija i perspektivy razvitija APK Rossii: materialy XIV Vserossijskoj nauchno-prakticheskoj konferencii molodyh uchenyh s mezhdunarodnym uchastiem, posvjashhennoj 300-letiju RAN. Kazan': Izd. AN RT. 2024; 111–114. doi: 10.37071/conferencearticle_67337e4099c5b5.25403234 (In Russ.).
- Shaikh T., Rub R.A., Sasikumar S. Antimicrobial screening of Cichorium intybus seed extracts. Arabian Journal of Chemistry. 2016; 9: 1569–1573. doi: 10.1016/j.arabjc.2012.04.012.
- Patent 2710270 (RF). Sredstvo, obladajushhee immunomodulirujushhej aktivnost'ju i sposob ego poluchenija. Sajbel' O.L., Dargaeva T.D., Radimich A.I. i dr.; №2019125854, zajavl. 16.08.2019; opubl. 25.12.2019. (In Russ.).
- Rukovodstvo po provedeniju doklinicheskih issledovanij lekarstvennyh sredstv. Chast' pervaja». Pod red. A.N. Mironova M.: Grif i K. 2012. (In Russ.).
- Tesjolkina A.D., Korozhan N.V., Kolchanova N.Je. Antimikrobnaja i protivogribkovaja aktivnost' izvlechenij iz travy cikorija obyknovennogo Vestnik farmacii 2017; 75(1): 47–51. (In Russ.).
Қосымша файлдар
