Development of a gel for administration to correct blood levels
- Authors: Dzhavakhyan M.A.1,2, Pavec N.R.2, Semkina O.A.2, Pupykina K.А.3, Kurkin D.V.1, Маrkaryan А.A.1
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Affiliations:
- Moscow State University of Medicine and Dentistry A.I. Evdokimova
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
- Bashkir State Medical University
- Issue: Vol 26, No 8 (2023)
- Pages: 12-21
- Section: Pharmaceutical chemistry
- URL: https://ogarev-online.ru/1560-9596/article/view/250534
- DOI: https://doi.org/10.29296/25877313-2023-08-02
- ID: 250534
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Abstract
Relevance. Medicinal plants are traditionally used as components that make up a healthy lifestyle program, prevention and treatment of certain diseases, including diabetes mellitus.
Aim: to develop and justify the composition of the gel for oral administration in the treatment of type 2 diabetes mellitus in a dosage form convenient for the patient for self-administration.
Material and methods. The object of the study is a standardized dense collection of the collection of the medicinal substance, the presence of rhizomes and high elecampane of high growth (Inula helenium L., rhizomata et radices), lingonberry leaves (Vaccinium vitis-idaea L., folia), rose hips (Rosa spp., fructus) and grass motherwort five-lobed or heart (Leonurus quinquelobatus Gilib. et
L. cardiaca L., herba) in probably 55%, 15%, 15%, 15%, respectively. Research methods meet the requirements of the RF GF.
Results. TAgar was chosen as a gelling agent for the dosage form, potassium sorbate as a preservative, and purified water as a solvent. The flavoring agent is erythritol. A method for determining inulin in a gel for oral administration has been developed.
Conclusion. A technology for obtaining a gel for oral administration has been developed, including the stages of obtaining a gel base and introducing a thick extract into the resulting base. A technique has been developed for the determination of inulin in a gel for oral administration. The quality indicators of the gel with a thick extract for oral administration were established according to the main indicators: appearance, uniformity, pH value, authenticity, quantitative determination of the inulin content.
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##article.viewOnOriginalSite##About the authors
M. A. Dzhavakhyan
Moscow State University of Medicine and Dentistry A.I. Evdokimova; All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Author for correspondence.
Email: akopovamarina13@mail.ru
Dr.Sc. (Pharm.), Associate Professor, Head of Director of the Scientific and Educational Institute of Pharmacy; Chief Research Scientist; гл. науч. сотрудник,
Russian Federation, MoscowN. R. Pavec
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: akopovamarina13@mail.ru
Applicant
Russian Federation, MoscowO. A. Semkina
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: akopovamarina13@mail.ru
Ph.D. (Pharm.), Leading Research Scientist
Russian Federation, MoscowK. А. Pupykina
Bashkir State Medical University
Email: akopovamarina13@mail.ru
Dr.Sc. (Pharm.), Professor of the Department of Pharmacognosy with a Course of Botany and the Basics of Phytotherapy
Russian Federation, UfaD. V. Kurkin
Moscow State University of Medicine and Dentistry A.I. Evdokimova
Email: akopovamarina13@mail.ru
Dr.Sc. (Pharm.), Director of the Scientific and Educational Institute of Pharmacy
Russian Federation, MoscowА. A. Маrkaryan
Moscow State University of Medicine and Dentistry A.I. Evdokimova
Email: akopovamarina13@mail.ru
Dr.Sc. (Pharm.), Vice-Rector
Russian Federation, MoscowReferences
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