Study of the psychotropic effect of glycyrrhiza glabra root extract under conditions of dapsone-induced exposure

Relevance. Dapsone (4,4'-diaminodiphenylsulfone) is used as a powerful antibacterial agent in the treatment of infectious diseases. Despite the complex pharmacological effect and high efficacy, dapsone has a number of negative properties, one of which is the occurrence of severe neuropsychiatric pathology with long-term use in the presence of predisposing factors. In this connection, correction of dapsone-induced changes on the part of various systems, including the nervous system, is an urgent task. As a means of correcting dapsone-induced neuropsychiatric changes, an extract of licorice naked horses can act.

The aim of the study was to evaluate the effect of licorice root extract on dapsone–induced changes in behavioral reactions and the severity of the psychomodulatory effect of licorice extract.

Material and methods. All experiments were carried out on white mongrel rats (6-8 months), which were divided into groups (n= 10): group 1 consisted of control rats receiving an equiobject of water for injection; group 2 - individuals receiving intragastric dapsone (Novartis; Switzerland) at a dose of 25 mg/kg for 28 days; group 3 – animals receiving intragastric dapsone at a dose of 25 mg / kg and licorice extract naked through a probe at a dose of 50 mg / kg for 28 days. The effect of licorice root extract on the behavioral reactions of rats under the conditions of course use of dapsone was evaluated using the "Porsolt" and "Open Field" tests.

Results. Against the background of intragastric administration of licorice root extract, there was a restoration of the ratio of immobilization time, active and passive swimming in the Porsolt test, an increase in horizontal and specific mink activity of animals, a decrease in the number of boluses, grooming and freezing in the "Open Field" test compared with the group of animals receiving intragastric dapsone.

Conclusions. Evaluation of the effect of licorice root extract on dapsone-induced changes in behavioral reactions showed the presence of an antidepressant and psychomodulatory effect in the extract, which can be used in the development of a psychocorrective agent based on this medicinal plant.