电邮这篇文章 Possibilities of modern methods of laboratory diagnostics in the study of viral hepatitis A
- 作者: Volchkova E.V.1, Belaya O.F.1, Umbetova K.T.1, Pshenichnaya N.Y.2, Malov V.A.1, Konnova Y.A.3
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隶属关系:
- The First Sechenov Moscow State Medical University
- Central Research Institute of Epidemiology
- Infectious diseases Hospital № 2
- 期: 卷 25, 编号 6 (2020)
- 页面: 264-268
- 栏目: CASE REPORTS
- URL: https://ogarev-online.ru/1560-9529/article/view/82724
- DOI: https://doi.org/10.17816/EID82724
- ID: 82724
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详细
It is generally accepted that the course of viral hepatitis A is accompanied by short-term viremia, and the disease itself does not have serious consequences for the person who has recovered. The article describes a clinical case of a protracted course of viral hepatitis A with long-term persistence of the virus. Against the background of the therapy, the patient's condition improved, and by the time of discharge from the hospital on the 38th day of illness and later, with a retrospective examination on the 68th day from the onset of the disease by the method of reverse transcription PCR (RT-PCR in real time), the presence of RNA of the hepatitis A virus was confirmed in feces, which indicated a long persistence of the virus in the body. This observation indicates the need for long-term dispensary observation of patients who have undergone viral hepatitis A.
作者简介
Elena Volchkova
The First Sechenov Moscow State Medical University
Email: antononina@rambler.ru
ORCID iD: 0000-0003-4581-4510
SPIN 代码: 3342-4681
MD, Dr. Sci. (Med), Professor
俄罗斯联邦, 8 bld. 2 Trubetskaya street, 119991, MoscowOlga Belaya
The First Sechenov Moscow State Medical University
Email: ofbelaya@mail.ru
ORCID iD: 0000-0002-2722-1335
SPIN 代码: 3921-7227
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 8 bld. 2 Trubetskaya street, 119991, MoscowKarina Umbetova
The First Sechenov Moscow State Medical University
Email: karinasara@inbox.ru
ORCID iD: 0000-0003-0902-9267
SPIN 代码: 3197-9205
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 8 bld. 2 Trubetskaya street, 119991, MoscowNatalia Pshenichnaya
Central Research Institute of Epidemiology
Email: natalia-pshenichnaya@yandex.ru
ORCID iD: 0000-0003-2570-711X
SPIN 代码: 5633-7265
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, MoscowValerii Malov
The First Sechenov Moscow State Medical University
Email: valmalov@list.ru
ORCID iD: 0000-0002-6157-1654
SPIN 代码: 4790-8986
MD, Dr. Sci. (Med.), Professor
俄罗斯联邦, 8 bld. 2 Trubetskaya street, 119991, MoscowYulia Konnova
Infectious diseases Hospital № 2
编辑信件的主要联系方式.
Email: konnova.yulia@gmail.com
ORCID iD: 0000-0003-3091-2433
SPIN 代码: 7856-0880
MD, Cand. Sci. (Med.)
俄罗斯联邦, Moscow参考
- Wilkinson BI, Rain T, Wiles K, et al. Oxford handbook of clinical medicine. Tenth edition. Oxford University Press; 2017. 278 p.
- Dienstag JL, Feinston SM, Kapikian AZ, et al. Faecal shedding of hepatitis A antigen. Lancet. 1975;1(7910):765–767. doi: 10.1016/s0140-6736(75)92434-4
- Zhou Y, Callendret B, Xu D, et al. Dominance of CD4(+) T helper cell response during acute resolving hepatitis A virus infection. J Exp Med. 2012;209(8):1481–1492. doi: 10.1084/jem.20111906
- Tong MJ, Thursby M, Rakela J, et al. Stadies on the maternal-infant transmission of the virus which cause acute hepatitis. Gastroenterology. 1981;80(5 Pt 1):999–1004.
- Pishke S, Vogel A, Jaeckel E, Manns MP. Immunopathogenesis of extrahepatic manifestations in HAV, HBV and HCV infections. In: Liver Immunology. Totowa, New Lersey: Humana Press; 2007. P. 209–217. doi: 10.1007/978-1-59745-518-3_17
- Choi HK, Song YG, Han SH, et al. Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A. J Clin Virol. 2011;52(3):192–197. doi: 10.1016/j.jcv.2011.07.013
- Vento S, Garofano C, Renzini C, et al. Identification of hepatitis A virus as a trigger for autoimmune cronic hepatitis type 1 in susceptible individuals. Lancet. 1991;337(8751):1183–1187. doi: 10.1016/0140-6736(91)92858-y
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