Chemistry of pyridoxine in drug design
- Авторы: Shtyrlin Y.G.1, Petukhov A.S.1, Strelnik A.D.1, Shtyrlin N.V.1, Iksanova A.G.1, Pugachev M.V.1, Pavelyev R.S.1, Dzyurkevich M.S.1, Garipov M.R.1, Balakin K.V.1
-
Учреждения:
- Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
- Выпуск: Том 68, № 5 (2019)
- Страницы: 911-945
- Раздел: Review
- URL: https://ogarev-online.ru/1066-5285/article/view/243365
- DOI: https://doi.org/10.1007/s11172-019-2504-5
- ID: 243365
Цитировать
Аннотация
Pyridoxine and its derivatives, pyridoxamine and pyridoxal, are the three main forms of vitamin B6, which play exceptionally important biological roles in living organisms. The active endogenous metabolites of these molecules, pyridoxal phosphate and pyridoxamine phosphate, are the most important coenzymes involved in a wide range of biochemical reactions necessary for cell activity, due to which pyridoxine and its derivatives are regarded as biologically privileged molecules. Taking into account also the wide possibilities for chemical modification of the pyridoxine structure, it is only natural for medicinal chemists to explore them in the design of novel drugs. This review summarizes the data on the main pharmacologically significant pyridoxine derivatives (including pyridoxamine and pyridoxal derivatives) reported in modern scientifi c and patent sources. Methods for their synthesis, key pharmacological properties, and medicinal chemistry concepts underlying the design of the developing physiologically active compounds are presented. The promising directions for future development of chemistry of physiologically active pyridoxine derivatives are also discussed.
Об авторах
Y. Shtyrlin
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Автор, ответственный за переписку.
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
A. Petukhov
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
A. Strelnik
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
N. Shtyrlin
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
A. Iksanova
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
M. Pugachev
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
R. Pavelyev
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
M. Dzyurkevich
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
M. Garipov
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
K. Balakin
Scientific and Educational Center of Pharmaceutics, Kazan (Volga Region) Federal University
Email: yurii.shtyrlin@gmail.com
Россия, 18 ul. Kremlevskaya, Kazan, 420008
Дополнительные файлы
