Naphthoquinone-derived polyol macrolides from natural sources


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New biologically active substances isolated from natural sources provide valuable information on structural motifs that are important for a specific type of activity and can also be used as drugs or serve as raw materials for chemical modification in order to develop new pharmaceuticals. This review considers natural antibiotics combining two pharmacophores in their structure: a redox-active naphthoquinone moiety and a membrane-active polyol macrolide. Data on their structures and the spectrum of biological activity are summarized.

Sobre autores

V. Alferova

Gause Institute of New Antibiotics

Email: ap2rin@gmail.com
Rússia, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021

M. Shuvalov

Gause Institute of New Antibiotics; Department of Chemistry, M. V. Lomonosov Moscow State University

Email: ap2rin@gmail.com
Rússia, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021; 1, Build. 3, Leninskie Gory, Moscow, 119991

V. Korshun

Gause Institute of New Antibiotics; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ap2rin@gmail.com
Rússia, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021; 16/10 ul. Miklukho-Maklaya, Moscow, 117997

A. Tyurin

Gause Institute of New Antibiotics; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Autor responsável pela correspondência
Email: ap2rin@gmail.com
Rússia, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021; 16/10 ul. Miklukho-Maklaya, Moscow, 117997

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