Email this article Naphthoquinone-derived polyol macrolides from natural sources
- Authors: Alferova V.A.1, Shuvalov M.V.1,2, Korshun V.A.1,3, Tyurin A.P.1,3
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Affiliations:
- Gause Institute of New Antibiotics
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 68, No 5 (2019)
- Pages: 955-966
- Section: Review
- URL: https://ogarev-online.ru/1066-5285/article/view/243367
- DOI: https://doi.org/10.1007/s11172-019-2506-3
- ID: 243367
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Abstract
New biologically active substances isolated from natural sources provide valuable information on structural motifs that are important for a specific type of activity and can also be used as drugs or serve as raw materials for chemical modification in order to develop new pharmaceuticals. This review considers natural antibiotics combining two pharmacophores in their structure: a redox-active naphthoquinone moiety and a membrane-active polyol macrolide. Data on their structures and the spectrum of biological activity are summarized.
About the authors
V. A. Alferova
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Russian Federation, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021
M. V. Shuvalov
Gause Institute of New Antibiotics; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: ap2rin@gmail.com
Russian Federation, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021; 1, Build. 3, Leninskie Gory, Moscow, 119991
V. A. Korshun
Gause Institute of New Antibiotics; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ap2rin@gmail.com
Russian Federation, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021; 16/10 ul. Miklukho-Maklaya, Moscow, 117997
A. P. Tyurin
Gause Institute of New Antibiotics; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: ap2rin@gmail.com
Russian Federation, 11 ul. Bolshaya Pirogovskaya, Moscow, 119021; 16/10 ul. Miklukho-Maklaya, Moscow, 117997
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