Complex  69m ZnLigCl 2  (Lig is  N -(5,6-dihydro-4 H -1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical

M. A. Orlova; T. P. Trofimova; A. P. Orlov; I. A. Ivanov; A. V. Severin; G. Yu. Aleshin; S. S. Belyshev; A. N. Vasiliev; S. N. Kalmykov

doi:10.1007/s11172-018-2136-1

Complex ^69mZnLigCl₂ (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical

Autores: Orlova M.A.¹^,2, Trofimova T.P.¹^,3, Orlov A.P.¹, Ivanov I.A.¹, Severin A.V.¹, Aleshin G.Y.¹, Belyshev S.S.⁴, Vasiliev A.N.¹, Kalmykov S.N.¹^,5
Afiliações:
1. Chemical Department, M. V. Lomonosov Moscow State University
2. Dmitry Rogachev National Medical Scientific Center of Pediatric Hematology, Oncology, and Immunology
3. Institute of Physiologically Active Compounds, Russian Academy of Sciences
4. D. V. Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
5. National Research Center “Kurchatov Institute,”
Edição: Volume 67, Nº 4 (2018)
Páginas: 774-778
Seção: Full Article
URL: https://ogarev-online.ru/1066-5285/article/view/242481
DOI: https://doi.org/10.1007/s11172-018-2136-1
ID: 242481

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Resumo

The cytotoxicity of complex ^69mZnLigCl₂ (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl) benzamide) against the K-562 cell line (chronic myeloid leukemia) was considered in comparison with the cells of healthy donors. The ^69mZnLigCl₂ complex was obtained and characterized by TLC and autoradiography methods. The kinetics of zinc sorption on hydroxyapatite was studied.

Sobre autores

M. Orlova

Chemical Department, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Medical Scientific Center of Pediatric Hematology, Oncology, and Immunology

Autor responsável pela correspondência
Email: orlova.radiochem@mail.ru
Rússia, Building 3, 1 Leninskie Gory, Moscow, Russian Federation, 119992; 1 ul. Samory Mashela, Moscow, Russian Federation, 117997

T. Trofimova

Chemical Department, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: orlova.radiochem@mail.ru
Rússia, Building 3, 1 Leninskie Gory, Moscow, Russian Federation, 119992; 1 Severnyi proezd, Chernogolovka, Moscow Region, Russian Federation, 142432