A new transformation of aminopyridines upon diazotization in acetonitrile with the formation of N-pyridinylacetamides

Аннотация

Diazotization of aminopyridines upon treatment with NaNO₂ and H₃PO₄ in acetonitrile led to the formation of N-pyridinylacetamides. This reaction constitutes a convenient and general preparative method for the synthesis of 2-, 3-, and 4-N-pyridinylacetamides under mild conditions in good yields. The in situ oxidation of the thus obtained N-pyridinylacetamides with hydrogen peroxide gave good yields of pyridinylacetamide N-oxides.