Email this article A new transformation of aminopyridines upon diazotization in acetonitrile with the formation of N-pyridinylacetamides
- Authors: Chudinov A.A.1, Dovbnya R.S.1, Krasnokutskaya E.A.1, Ogorodnikov V.D.2, Filimonova I.L.3
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Affiliations:
- National Research Tomsk Polytechnic University
- Institute of Petroleum Chemistry, Siberian Branch of the Russian Academy of Sciences
- Siberian State Medical University
- Issue: Vol 65, No 9 (2016)
- Pages: 2312-2314
- Section: Brief Communications
- URL: https://ogarev-online.ru/1066-5285/article/view/239028
- DOI: https://doi.org/10.1007/s11172-016-1583-9
- ID: 239028
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Abstract
Diazotization of aminopyridines upon treatment with NaNO2 and H3PO4 in acetonitrile led to the formation of N-pyridinylacetamides. This reaction constitutes a convenient and general preparative method for the synthesis of 2-, 3-, and 4-N-pyridinylacetamides under mild conditions in good yields. The in situ oxidation of the thus obtained N-pyridinylacetamides with hydrogen peroxide gave good yields of pyridinylacetamide N-oxides.
About the authors
A. A. Chudinov
National Research Tomsk Polytechnic University
Email: eak@tpu.ru
Russian Federation, 30 prosp. Lenina, Tomsk, 634050
R. S. Dovbnya
National Research Tomsk Polytechnic University
Email: eak@tpu.ru
Russian Federation, 30 prosp. Lenina, Tomsk, 634050
E. A. Krasnokutskaya
National Research Tomsk Polytechnic University
Author for correspondence.
Email: eak@tpu.ru
Russian Federation, 30 prosp. Lenina, Tomsk, 634050
V. D. Ogorodnikov
Institute of Petroleum Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: eak@tpu.ru
Russian Federation, 4 prosp. Akademicheskii, Tomsk, 634021
I. L. Filimonova
Siberian State Medical University
Email: eak@tpu.ru
Russian Federation, 2 Moskovskii trakt, Tomsk, 634050
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