Email this article Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
- Authors: Tereshchenko O.G.1, Nikolskaya E.D.1, Zhunina O.A.1, Zavarzina V.V.2, Yabbarov N.G.1, Fomicheva M.V.1, Zubkov E.V.1,3, Sokol M.B.1, Gukasova N.V.2, Severin E.S.1
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Affiliations:
- Russian Research Center for Molecular Diagnostics and Therapy
- National Research Center “Kurchatov Institute”
- Sechenov University, Ministry of Health of the Russian Federation
- Issue: Vol 67, No 12 (2018)
- Pages: 2290-2296
- Section: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/243233
- DOI: https://doi.org/10.1007/s11172-018-2372-4
- ID: 243233
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Abstract
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
About the authors
O. G. Tereshchenko
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
E. D. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
O. A. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy
Author for correspondence.
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
V. V. Zavarzina
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Russian Federation, 1 pl. Akad. Kurchatova, Moscow, 123098
N. G. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
M. V. Fomicheva
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
E. V. Zubkov
Russian Research Center for Molecular Diagnostics and Therapy; Sechenov University, Ministry of Health of the Russian Federation
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638; 2 Build., 8 ul. Trubetskaya, Moscow, 119991
M. B. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
N. V. Gukasova
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Russian Federation, 1 pl. Akad. Kurchatova, Moscow, 123098
E. S. Severin
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Russian Federation, 8 Simferopol´skii b-r, Moscow, 117638
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