Email this article Antioxidant properties of chitosan-(poly)nitroxides under induced oxidative stress
- Authors: Balakina A.A.1,2,3, Mumyatova V.A.1,2,3, Pliss E.M.2, Terent’ev A.A.1,2,3,4, Sen’ V.D.1,2
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- P. G. Demidov Yaroslavl State University
- Research and Education Center “Medicinal Chemistry” in Chernogolovka, Moscow Region State University
- Faculty of Fundamental Physical and Chemical Engineering, M. V. Lomonosov Moscow State University
- Issue: Vol 67, No 11 (2018)
- Pages: 2135-2140
- Section: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/243202
- DOI: https://doi.org/10.1007/s11172-018-2341-y
- ID: 243202
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Abstract
The cytotoxicity and antioxidant properties of water-soluble (at physiological pH) chitosan- (poly)nitroxides (CPNs) containing pyrroline-based nitroxide and having different molecular weights of the polysaccharide backbone were studied on normal (Vero) and tumor (HepG2) cell models. The compounds were found to exhibit low cytotoxicity and to effectively reduce the level of reactive oxygen species (ROS) generated upon the breakdown of tert-butyl hydroperoxide in normal cells. In tumor cells, the CPNs have little effect on the ROS level under the oxidative stress. The results show that CPNs also represent a promising platform for the development of cell delivery systems for biologically active compounds.
About the authors
A. A. Balakina
Institute of Problems of Chemical Physics, Russian Academy of Sciences; P. G. Demidov Yaroslavl State University; Research and Education Center “Medicinal Chemistry” in Chernogolovka, Moscow Region State University
Author for correspondence.
Email: balakina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; 14 Sovetskaya ul., Yaroslavl, 150003; 24 ul. Very Voloshinoi, Mytishchi, Moscow Region, 141014
V. A. Mumyatova
Institute of Problems of Chemical Physics, Russian Academy of Sciences; P. G. Demidov Yaroslavl State University; Research and Education Center “Medicinal Chemistry” in Chernogolovka, Moscow Region State University
Email: balakina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; 14 Sovetskaya ul., Yaroslavl, 150003; 24 ul. Very Voloshinoi, Mytishchi, Moscow Region, 141014
E. M. Pliss
P. G. Demidov Yaroslavl State University
Email: balakina@icp.ac.ru
Russian Federation, 14 Sovetskaya ul., Yaroslavl, 150003
A. A. Terent’ev
Institute of Problems of Chemical Physics, Russian Academy of Sciences; P. G. Demidov Yaroslavl State University; Research and Education Center “Medicinal Chemistry” in Chernogolovka, Moscow Region State University; Faculty of Fundamental Physical and Chemical Engineering, M. V. Lomonosov Moscow State University
Email: balakina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; 14 Sovetskaya ul., Yaroslavl, 150003; 24 ul. Very Voloshinoi, Mytishchi, Moscow Region, 141014; Build. 51, 1 Leninskie Gory, Moscow, 119991
V. D. Sen’
Institute of Problems of Chemical Physics, Russian Academy of Sciences; P. G. Demidov Yaroslavl State University
Email: balakina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; 14 Sovetskaya ul., Yaroslavl, 150003
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