Synthesis of ivermectin-4″,5-diyl[bis( N -methylcarbamate)]

A. N. Blinnikov; E. I. Chernoburova; N. G. Kolotyrkina; M. A. Shchetinina; V. A. Lishchuk; K. L. Ovchinnikov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

doi:10.1007/s11172-018-2145-0

Synthesis of ivermectin-4″,5-diyl[bis(N-methylcarbamate)]

Authors: Blinnikov A.N.¹, Chernoburova E.I.¹, Kolotyrkina N.G.¹, Shchetinina M.A.¹, Lishchuk V.A.², Ovchinnikov K.L.², Kolobov A.V.², Dzhafarov M.K.², Vasilevich F.I.², Zavarzin I.V.¹
Affiliations:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Issue: Vol 67, No 5 (2018)
Pages: 833-835
Section: Full Articles
URL: https://ogarev-online.ru/1066-5285/article/view/242508
DOI: https://doi.org/10.1007/s11172-018-2145-0
ID: 242508

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Abstract

New ivermectin-4″,5-diyl[bis(N-methylcarbamate)] was synthesized by the MoO₂Cl₂(DMF)₂-catalyzed reaction of ivermectin with methyl isocyanate. The synthesized compound could find application as antiparasitic agent.

About the authors

A. N. Blinnikov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991

E. I. Chernoburova

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991

N. G. Kolotyrkina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991

M. A. Shchetinina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991