Email this article Silicon–boron-containing glycerohydrogel having wound healing, regenerative, and antimicrobial activity
- Authors: Chupakhin O.N.1,2, Khonina T.G.1, Kungurov N.V.3, Zilberberg N.V.3, Evstigneeva N.P.3, Kokhan M.M.3, Polishchuk A.I.3, Shadrina E.V.1, Larchenko E.Y.1, Larionov L.P.4, Karabanalov M.S.2
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Affiliations:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Brunch of Russian Academy of Sciences
- Ural Federal University
- Ural Research Institute for Dermatology, Venereology and Immunopathology
- Ural State Medical University
- Issue: Vol 66, No 3 (2017)
- Pages: 558-563
- Section: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/240309
- DOI: https://doi.org/10.1007/s11172-017-1771-2
- ID: 240309
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Abstract
A novel combined bioactive silicon–boron-containing glycerohydrogel was prepared by a sol-gel method with the use of silicon and boron glycerolates as precursors. The solid phase of hydrogel was separated by an exhaustive cold extraction and characterized by XRD, atomic emission spectroscopy, IR spectroscopy, and elemental analysis data. Liquid medium of hydrogel was characterized by atomic emission spectroscopy and 11B NMR spectroscopy techniques. The structural features of the hydrogel were studied using transmission electron microscopy; the model of structure was proposed. Silicon–boron-containing hydrogel displays pronounced wound healing, regenerative and antimicrobial activities and could be recommended for more extensive study with the purpose to be applied in medical practice.
About the authors
O. N. Chupakhin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Brunch of Russian Academy of Sciences; Ural Federal University
Email: khonina@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoy, 20 ul. Akademicheskaya, Ekaterinburg, 620041; 19 ul. Mira, Ekaterinburg, 620002
T. G. Khonina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Brunch of Russian Academy of Sciences
Author for correspondence.
Email: khonina@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoy, 20 ul. Akademicheskaya, Ekaterinburg, 620041
N. V. Kungurov
Ural Research Institute for Dermatology, Venereology and Immunopathology
Email: khonina@ios.uran.ru
Russian Federation, 8 ul. Scherbakova, Ekaterinburg, 620076
N. V. Zilberberg
Ural Research Institute for Dermatology, Venereology and Immunopathology
Email: khonina@ios.uran.ru
Russian Federation, 8 ul. Scherbakova, Ekaterinburg, 620076
N. P. Evstigneeva
Ural Research Institute for Dermatology, Venereology and Immunopathology
Email: khonina@ios.uran.ru
Russian Federation, 8 ul. Scherbakova, Ekaterinburg, 620076
M. M. Kokhan
Ural Research Institute for Dermatology, Venereology and Immunopathology
Email: khonina@ios.uran.ru
Russian Federation, 8 ul. Scherbakova, Ekaterinburg, 620076
A. I. Polishchuk
Ural Research Institute for Dermatology, Venereology and Immunopathology
Email: khonina@ios.uran.ru
Russian Federation, 8 ul. Scherbakova, Ekaterinburg, 620076
E. V. Shadrina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Brunch of Russian Academy of Sciences
Email: khonina@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoy, 20 ul. Akademicheskaya, Ekaterinburg, 620041
E. Yu. Larchenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Brunch of Russian Academy of Sciences
Email: khonina@ios.uran.ru
Russian Federation, 22 ul. S. Kovalevskoy, 20 ul. Akademicheskaya, Ekaterinburg, 620041
L. P. Larionov
Ural State Medical University
Email: khonina@ios.uran.ru
Russian Federation, 3 ul. Repina, Ekaterinburg, 620219
M. S. Karabanalov
Ural Federal University
Email: khonina@ios.uran.ru
Russian Federation, 19 ul. Mira, Ekaterinburg, 620002
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