Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

R. S. Pavelyev; R. R. Khairullina; S. A. Koshkin; A. G. Iksanova; O. A. Lodochnikova; N. N. Khaertdinov; G. F. Sitdikova; A. F. Safina; E. G. Aleksandrova; L. E. Ziganshina; Yu. G. Shtyrlin

doi:10.1007/s11172-016-1332-0

Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine

作者: Pavelyev R.S.¹, Khairullina R.R.¹, Koshkin S.A.¹, Iksanova A.G.¹, Lodochnikova O.A.², Khaertdinov N.N.¹, Sitdikova G.F.¹, Safina A.F.¹, Aleksandrova E.G.¹, Ziganshina L.E.¹, Shtyrlin Y.G.¹
隶属关系:
1. Kazan (Volga Region) Federal University
2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
期: 卷 65, 编号 2 (2016)
页面: 519-531
栏目: Full Articles
URL: https://ogarev-online.ru/1066-5285/article/view/237242
DOI: https://doi.org/10.1007/s11172-016-1332-0
ID: 237242

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An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.