Email this article Synthesis and fungicidal activity of substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols
- Authors: Popkov S.V.1, Makarenko A.A.1, Nikishin G.I.2
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Affiliations:
- D. I. Mendeleev University of Chemical Technology of Russia
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Issue: Vol 65, No 2 (2016)
- Pages: 513-518
- Section: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/237231
- DOI: https://doi.org/10.1007/s11172-016-1331-1
- ID: 237231
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Abstract
A series of halogen substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols were obtained from spiro[4.5]decan-6-one in three steps: Claisen—Schmidt condensation with substituted benzaldehydes, conversion of 7-benzylidenespiro[4.5]decan-6-ones to oxiranes by reaction with dimethylsulphonium methylide followed by ring opening of oxiranes with 1,2,4-triazole or imidazole. In vitro testing of fungicidal activity of synthesized compounds against seven phytopathogenic fungi showed, that a number of compounds are more active than triadimenol.
About the authors
S. V. Popkov
D. I. Mendeleev University of Chemical Technology of Russia
Author for correspondence.
Email: popkovsv@rctu.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
A. A. Makarenko
D. I. Mendeleev University of Chemical Technology of Russia
Email: popkovsv@rctu.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047
G. I. Nikishin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: popkovsv@rctu.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
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