Modification of an Anion-Exchange Procedure for  68 Ga Preconcentration and Automated Synthesis of [ 68 Ga]Ga-PSMA-11

D. O. Antuganov; D. V. Ryzhkova; V. V. Timofeev; T. A. Zykova; Yu. O. Antuganova; K. Yu. Timofeeva; O. P. Samburov; M. P. Zykov

doi:10.1134/S1066362219060183

Modification of an Anion-Exchange Procedure for ⁶⁸Ga Preconcentration and Automated Synthesis of [⁶⁸Ga]Ga-PSMA-11

Authors: Antuganov D.O.¹, Ryzhkova D.V.¹, Timofeev V.V.¹, Zykova T.A.¹, Antuganova Y.O.¹, Timofeeva K.Y.¹, Samburov O.P.¹, Zykov M.P.¹
Affiliations:
1. Almazov National Medical Research Centre
Issue: Vol 61, No 6 (2019)
Pages: 748-753
Section: Article
URL: https://ogarev-online.ru/1066-3622/article/view/225398
DOI: https://doi.org/10.1134/S1066362219060183
ID: 225398

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Abstract

An anion-exchange procedure for concentrating ⁶⁸Ga produced from a ⁶⁸Ga/⁶⁸Ge generator (Cyclotron Company, Russia) was studied systematically. The procedure for preparing [⁶⁸Ga]Ga-PSMA-11 of the quality meeting all the requirements for clinical use in a high yield (58 ± 3% or the activity eluted from the generator, n = 10) was developed. Synthesis of [⁶⁸Ga]Ga-PSMA-11 was performed on an automated unit designed at the Almazov National Medical Research Centre.