Prognosis of Post-Radiation Dynamics of Blood Neutrophil Count in Cases of Acute Uneven Irradiation (Cytogenetic Studies)

Abstract

The results of applying the method of prognosis of post-radiation curves of neutrophil count dynamics in the blood after acute nonuniform human irradiation based on the use of a special computer program and the results of cytogenetic analysis of the cultures of peripheral blood lymphocytes are presented. The computer program converts the distribution of the cells by the number of dicentrics in them into the distribution of lymphocytes by dose received. Data obtained from 10 patents injured in six different radiation incidents were processed. To take into account radiation-induced proliferation delay and interphase cell death, correction of the observed distributions of dicentric chromosomes was carried out. The comparison of real and predicted curves of neutrophil count dynamics indicates in general their satisfactory compliance.