Interrelation between the Contractile Activity of the Myocardium and the Level of Oxidative Stress in Rats under Concomitant Development of Postinfarction Cardiosclerosis and Diabetes Mellitus

Abstract

The features of the functional state of the rat myocardium and the activity of the lipid peroxidation processes were studied under the conditions of concomitant development of heart failure of ischemic etiology and diabetes mellitus. The rhythmoinotropic myocardial reaction and the content of active products of thiobarbituric acid and diene conjugates in the blood plasma of rats with postinfarction and diabetic heart remodeling were assessed separately and under their combined development. Under experimental conditions with the development of post-infarction cardiac remodeling, it was shown that the induction of diabetes leads to suppression of the increase in the activity of lipid peroxidation and maintenance of myocardial rhythmoinotropic reactions.