Proteasomes and transplantology: Current state of the problem and the search for promising trends

Ya. D. Karpova; G. A. Bozhok; N. M. Alabedal’karim; Yu. V. Lyupina; T. M. Astakhova; E. I. Legach; N. P. Sharova

doi:10.1134/S1062359017030049

Proteasomes and transplantology: Current state of the problem and the search for promising trends

Authors: Karpova Y.D.¹, Bozhok G.A.², Alabedal’karim N.M.², Lyupina Y.V.¹, Astakhova T.M.¹, Legach E.I.², Sharova N.P.¹
Affiliations:
1. Koltsov Institute of Developmental Biology
2. Institute of Problems in Cryobiology and Cryomedicine
Issue: Vol 44, No 3 (2017)
Pages: 237-244
Section: Biochemistry
URL: https://ogarev-online.ru/1062-3590/article/view/182394
DOI: https://doi.org/10.1134/S1062359017030049
ID: 182394

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Abstract

Basic research of the structure and functions of multiple forms of proteasomes is overviewed. The proteasomes of liver, acting as a primary lymphoid organ in embryogenesis, displaying nonspecific local immunity, and providing development of tolerance to food and other foreign antigens during the lifespan, are described. The role of individual forms of liver proteasomes in transplantology is considered as well as their utility as markers for endocrine transplant survival.