Gold nanoparticles: Mutagen, antimutagen, or comutagen?

S. T. Zakhidov; N. M. Mudzhiri; V. M. Rudoy; O. V. Dement’eva; A. A. Makarov; I. A. Zelenina; T. L. Marshak

doi:10.1134/S1062359017030128

Gold nanoparticles: Mutagen, antimutagen, or comutagen?

Authors: Zakhidov S.T.¹, Mudzhiri N.M.¹^,2, Rudoy V.M.³, Dement’eva O.V.³, Makarov A.A.⁴, Zelenina I.A.¹, Marshak T.L.²
Affiliations:
1. Faculty of Biology
2. Koltzov Institute of Developmental Biology
3. Frumkin Institute of Physical Chemistry and Electrochemistry
4. Higher School of Economics National Research University
Issue: Vol 44, No 3 (2017)
Pages: 233-236
Section: Developmental Biology
URL: https://ogarev-online.ru/1062-3590/article/view/182393
DOI: https://doi.org/10.1134/S1062359017030128
ID: 182393

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Abstract

The effect of ultrasmall gold nanoparticles (GNPs), both direct and in combination with the alkylating mutagen dipin, on the genetic structures of male germ cells in mice were studied using the meiotic micronucleus assay. It was shown for the first time that GNPs can exhibit mutagenic, antimutagenic, and comutagenic activity depending on the experimental conditions.