FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY OF MALIGNANT GLIOMAS IN RATS


Cite item

Full Text

Abstract

The possibilities of fl uorescence diagnosis (FD) and photodynamic therapy (PDT) with domestic photosensitizers and domestic equipment in brain tumors have been studied. Investigation of the level and selectivity of accumulation dynamics of Photosens and Tiosens in C6 glioma tissue by spectral fl uorescence method has showed the selective accumulation of both agents in tumor tissue. High effi ciency of PDT with Photosens and Tiosens both as monotherapy and as combined treatment has been shown on the base of pathomorphological criteria. Increase of therapeutic effi cacy of combined treatment of C6 glioma using FD and intraoperative PDT with Alasens has been established.

About the authors

I. Yu Kubasova

N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Science

Z. S Smirnova

N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Science

Email: smirnova_z@mail.ru
д-р мед. наук, проф., зав. лаб. экспериментальной химиотерапии НИИ экспериментальной диагностики и терапии опухолей РОНЦ

K. V Ermakova

N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Science

L. M Borisova

N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Science

M. P Kiseleva

N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Science

N. A Oborotova

N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Science

G. A Meerovich

A.M.. Prokhorov General Physics Institute of the Russian Academy of Science

V. M Derkacheva

FSUE «SSC» NIOPIK

References

  1. Stylli S. S., Kaye A. H., Macgregor L. et al. Photodynamic therapy of high grade glioma - long term survival. J. Clin. Neurosci. 2005; 12 (4): 389-98.
  2. Zhang X., Jiang F., Kalkanis S. N. et al. Combination of surgical resection and photodynamic therapy of 9L gliosarcoma in the nude rat. Photochem Photobiol. 2006; 82 (6): 1704-11.
  3. Muller P. J., Wilson B. C. Photodynamic therapy of brain tumors -a work in progress. Lasers Surg. Med. 2006; 38 (5): 384-9.
  4. Fenstermaker R. A., Ciesielski M. J. Immunotherapeutic strategies for malignant glioma. Cancer Control. 2004; 11 (3): 181-91.
  5. Yang V. X., Muller P. J., Herman P., Wilson B. C. A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumors. Lasers Surg. Med. 2003; 32 (3): 224-32.
  6. Stummer W., Pichlmeier U., Meinel T. et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006; 7: 392-401.
  7. Lilge L., Portnoy M., Wilson B. C. Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue. Br. J. Cancer. 2000; 83 (8): 1110-17.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Eco-Vector


 


Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).