LATE RADIATION DAMAGES DURING DIFFERENTLY FRACTIONATED CHEMORADIOTHERAPY FOR OROPHARYNGEAL CANCER

The tolerability of chemoradiotherapy procedures by irregularly adjusting a daily dose and standard radiation was studied by the toxic effect of late radiation damage to the normal tissues and organs of the oral cavity and oropharynx. There were 221 clinical cases of primary cancer of the oral and oropharyngeal mucosa. Late radiation damages to normal tissues and organs occurred in 31 (14%) of the 221 treated patients in different periods. Moreover, they happened in 20.2% of the patients after radiation therapy and in 8.9 and 10.8% after chemoradiotherapy by dividing the dose into 1+1.5 and 1+2 Gy, respectively (p > 0.05). The findings suggest that the tolerability of simultaneous differently fractionated chemoradiotherapy is satisfactory according to the late toxicity criteria - radiation damage to normal tissues and organs in the radiation area.

chemoradiotherapy, late radiation damages, differently fractionated radiation, osteoradionecrosis