RESULTS OF SURGICAL AND COMBINATION TREATMENT FOR RECTAL CANCER


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Abstract

The results of surgical versus combination treatment for rectal cancer (RC) were analyzed. Changing from the standard, the so-called orthodox, surgery for RC to total mesorectumectomy (TME) could considerably reduce the rate of local recurrences and improve the functional results of treatment. However, there has still been no general use of TME as the operation of choice for RC. The results of examining and treating 542 patients with stage I-IV RC treated at the Herzen Moscow Oncology Research Institute in 1982 to 2010 inclusive were studied. Combination treatment was performed in 242 patients. TME was used in 112 patients. The mean duration of surgery was 211.4±79.1 and 282.2±67.9 min in the non-TME and TME groups, respectively (p < 0.05). In these groups, the frequency of early postoperative complications was 43.3 and 24.1%, respectively (χ 2 = 15.31; p = 0.0009). In the TME group patients who had undergone potentially radical operations, three-year overall survival was 85.9% versus 67.4% in the non-TME group (p = 0.181). In these groups, tumor-specific survival was 89.1 and 77.0%, respectively (p = 0.116).

About the authors

V. I. Chissov

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

G. A. Frank

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

D. V. Sidorov

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

д-р мед. наук, рук. абдоминального отд-ния

O. A. Mainovskaya

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

A. A. Troitsky

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

M. V. Lozhkin

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

N. A. Grishin

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

L. O Petrov

P. A. Herzen Moscow Oncology Research Institute, Ministry of Health and Social Development of the Russian Federation

References

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