TUMOR STEM CELLS AND THEIR MICRO-ENVIRONMENT: THE ROLE IN THE DEVELOPMENT OF THE TUMOR
- 作者: Sagakyants A.B.1, Novikova I.A.1, Ulyanova E.P.1, Zolotareva E.I.1, Shaposhnikov A.V.1, Dzhenkova E.A.1
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隶属关系:
- Rostov Research Institute of Oncology
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 512-514
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120286
- DOI: https://doi.org/10.31857/S102872210006948-7
- ID: 120286
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详细
Cancer stem cells (CSC) are a special functional group of cells in a heterogeneous tumor population, causing both the maintenance and growth of a tumor, metastasis processes, and resistance to various chemotherapeutic drugs. The questions of a comprehensive study of the dynamics of the structural and functional organization of CSC niches, the role of its individual components in maintaining these cells and prognosis of their future behavior remain topical. This paper is devoted to the consideration of the biological properties of cancer stem cells, their interaction with some components of their microenvironment and the role of this interaction in maintaining the properties of CSC.
作者简介
A. Sagakyants
Rostov Research Institute of Oncology
编辑信件的主要联系方式.
Email: asagak@rambler.ru
Ph.D., Associate Professor, Head of the Laboratory of Immunophenotyping of tumors,
Rostov-on-Don
俄罗斯联邦I. Novikova
Rostov Research Institute of Oncology
Email: fake@neicon.ru
PhD, Deputy General Director for Science,
Rostov-on-Don
俄罗斯联邦E. Ulyanova
Rostov Research Institute of Oncology
Email: fake@neicon.ru
research fellow, Laboratory of Immunophenotyping of tumors,
Rostov-on-Don
俄罗斯联邦E. Zolotareva
Rostov Research Institute of Oncology
Email: fake@neicon.ru
research fellow, Laboratory of Immunophenotyping of tumors,
Rostov-on-Don
俄罗斯联邦A. Shaposhnikov
Rostov Research Institute of Oncology
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor, Chief Researcher of the Thoraco-Abdominal Department,
Rostov-on-Don
俄罗斯联邦E. Dzhenkova
Rostov Research Institute of Oncology
Email: fake@neicon.ru
Doctor of Biological Sciences, Associate Professor, Scientific secretary,
Rostov-on-Don
俄罗斯联邦参考
- Papaccio F., Paino F., Regad T., Papaccio G., Desiderio B., Tirino V. Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development// Stem Cells Translational medicine, 2017. 6: P. 2115–2125.
- Sultan M., Coyle K. M., Vidovic D., Thomas M. L., Gujar S., Marcato P. Hide-and-seek: the interplay between cancer stem cells and the immune system// Carcinogenesis, 2017, Vol. 38, No. 2, 107–118.
- Scheel C., Eaton E. N., Li S. et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast // Cell, 2011. – 145(6): P. 926–40.
- Kim Y., Kahn M. The role of the Wnt signaling pathway in cancer stem cells: prospects for drug development // Res. Repor. Biochem., 2014. – 4: P. 1–12.
- Ridge S. M., Sullivan F. J., Glynn S. A. Mesenchymal stem cells: Key players in cancer progression // Mol Cancer, 2017. –16: p. 31.
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