THE PROLONGATED EFFECTS OF BETA-ENDORPHIN ON MOUSE IL-1BETA, IL-2, IL-4 AND IL-10 SECRETION IN VIVO
- 作者: Baeva T.A.1, Tendryakova S.P.1,2
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms
- Perm State University
- 期: 卷 20, 编号 2 (2017)
- 页面: 246-248
- 栏目: Articles
- URL: https://ogarev-online.ru/1028-7221/article/view/119777
- ID: 119777
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详细
Beta-endorphin is a compound of peptide nature with a high regulatory activity on the immune system. The existence of long-term immunoregulatory effects of beta-endorphin is of great interest.This work describes the beta-endorphin effects on the corticosterone levels in plasma, as well as the production of key regulatory cytokines by murine splenocytes and macrophages. The dependence of the beta-endorphin effects from the used dose and exposure time was shown.
作者简介
T. Baeva
Institute of Ecology and Genetics of Microorganisms
编辑信件的主要联系方式.
Email: noemail@neicon.ru
俄罗斯联邦
S. Tendryakova
Institute of Ecology and Genetics of Microorganisms; Perm State University
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Smith M. E. Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis. Brain Behav. Immun. 2008, 22, 3-14.
- Sunal R., Tuncel N., Sumer N. Effect of beta-endorphin and cold stress on heart noradrenalin levels in rats. Ann. N. Y. Acad. Sci. 1987, 496, 158-160.
- Фримель Г. Иммунологические методы. Издательство «Медицина», 1987; 472 с.
- Гейн С. В., Баева Т. А., Небогатиков В. О., Тендрякова С. П. Влияние бета-эндорфина на антителогенез, пролиферацию и секрецию Tх1/Tх2-цитокинов in vivo. Бюллетень экспериментальной биологии и медицины, 2011, 11,526-529.
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