REACTION OF CELLULAR FACTORS IN INNATE AND ADAPTIVE IMMUNITY OF THE PIGLETS ON THE INTRODUCTION OF THE DRUG «ANANDIN»
- 作者: Кryachko O.V.1, Khomenko R.M.1
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隶属关系:
- St. Petersburg State Academy of Veterinary Medicine
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 822-824
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119667
- DOI: https://doi.org/10.31857/S102872210006685-8
- ID: 119667
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详细
The purpose of this study is to study the eff ect of the drug “Anandin” on some cellular factors of innate and adaptive immunity in piglets. “Anandin” is a drug from the group of immunomodulators that contains two types of compounds, these are derivatives of acridone acetic acid, as well as nitrogencontaining a-D-glucofurase. For the experiment, 30 piglets were selected 15 days before weaning (40 days old). The mass and physiological state of the animals was the same. The study involved a single administration of 10% solution “Anandin” experimental group of animals at a dose of 15 mg/kg body weight. The control group was intact. Before and after the introduction of the drug were carried out laboratory blood tests. The results showed that “Anandin” has a positive eff ect on the performance of cellular factors of immunity. The parameters studied: the activity of oxygen-dependent and oxygen-independent bactericidal systems of neutrophils (LKT and NBT-stimulated), production of lymphokines in RTML, removal of antigens (level of circulating immune complexes).
作者简介
O. Кryachko
St. Petersburg State Academy of Veterinary Medicine
编辑信件的主要联系方式.
Email: pathophys-spbgavm@yandex.ru
Dr., Prof., Head of the Department of Pathological Physiology,
Sankt-Petersburg
俄罗斯联邦R. Khomenko
St. Petersburg State Academy of Veterinary Medicine
Email: fake@neicon.ru
Ph.D., Assistant, Department of Pathological Physiology,
Sankt-Petersburg
俄罗斯联邦参考
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- Хоменко Р. М. Ветеринарно-гигиеническая оценка использования «Анандина» на свиноматках и поросятах: дис…канд. вет.наук. Санкт-Петербург, 2006. –107 с.
- Takamatsu H.-H., Denyer M. S., Stirling C. M.A., Netherton C. L., Oura C. A.L., Lacasta A., Argilaguet J. M., Rodríguez F., Martins C. Cellular immunity in ASFV responces // Virus Research. 2013. Т. 173. № 1. P. 110–121.
- Методические рекомендации по проведению иммунологических исследований: Методы оценки Т- и В-систем иммунитета/ Воен.-мед. акад. Подгот. В. Г. Морозов, В. Х. Хавинсон. – Л., 1980. – 43 с.
- Хоменко Р. М., Крячко О. В., Лукоянова Л. А. Влияние препарата «Анандин»® на некоторые иммунологические показатели у свиноматок в период супоросности и лактации.// Международный вестник ветеринарии. 2018. № 3. С. 58–62.
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