FEATURES OF CYTOKINE PRODUCTION EX VIVO IN CHILDREN UNDER STRONTIUM EXPOSURE
- 作者: Starkova K.G.1, Otavina E.A.1
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隶属关系:
- FBUN Federal Research Center for Medical and Preventive Health Risk Management Technologies
- 期: 卷 22, 编号 3 (2019)
- 页面: 1284-1288
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119648
- DOI: https://doi.org/10.31857/S102872210007272-4
- ID: 119648
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The features of spontaneous and induced synthesis of cytokines ex vivo in children under strontium exposure were analyzed. The levels of spontaneous, mitogen-induced (phytohemagglutinin 4 μg/ml, concavalin A 4 μg/ml, lipopolysaccharide 2 μg/ml) and strontium (0.01 mg/ml) cytokine production in supernatants of whole peripheral blood of children living in the endemic area of stable strontium exposure were determined by enzyme immunoassay. When compared to the spontaneous production of cytokines by peripheral blood cells of children in the observation group, we revealed a significant decrease in IL-12 levels by 3.1 times, TNF-α by 5.6 times regarding the comparison group and the absence of differences in the spontaneous synthesis of IL-6, IL-10, IL-17, GM-CSF. Under the conditions of inducing effect of strontium, a decrease in production of TNF-α, IL-6, IL-12, IL-17, GM-CSF was found to be by 5.0, 1.7, 2.4, 1.6, 5.0 times, respectively, at the overall stimulating effect of the metal on the indicators of the observation group, IL-6 by 133.1 times, IL-12 by 1.4 times, GM-CSF by 2.2 times, TNF-α by 1.8 times. The data obtained indicate a modulating effect of strontium on cytokine production in whole blood cultures with a predominantly activating effect on mediators of the pro-infl ammatory action of IL-6, IL-12, GM-CSF, TNF-α.
作者简介
K. Starkova
FBUN Federal Research Center for Medical and Preventive Health Risk Management Technologies
编辑信件的主要联系方式.
Email: fake@neicon.ru
PhD (Biology), Head of the laboratory of immunology and allergology,
614045 Perm, Monastyrskaya St., 82
俄罗斯联邦E. Otavina
FBUN Federal Research Center for Medical and Preventive Health Risk Management Technologies
Email: fake@neicon.ru
PhD (Biology), laboratory of immunology and allergology,
Perm
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