THE INDICES OF IMMUNITY AND THE CLINICAL COURSE OF POSTTRAUMATIC PERIOD IN PATIENTS WITH PENETRATING WOUNDS OF THE EYEBALL WHEN INCLUDED IN A COMPREHENSIVE TREATMENT OF THE DRUG BESTIM

We conducted a study of indicators of systemic immunity and the clinical course of post-traumatic period in 38 patients with penetrating wounds of the eyeball severe. In the first group 20 patients received pathogenetic basic treatment, in the second group 18 patients in the standard treatment included intramuscular injection of immunomodulator Bestim 100 mcg daily for 5 days, starting 3 days after the injury. We studied subpopulation composition of lymphocytes in the blood serum on 2-3 and 10 days after injury, the timing of the relief of the inflammatory symptoms, the clinical course of posttraumatic period at 14 and 30 days after injury. It was established that the inclusion of the immunomodulator Bestim in the basic treatment of the PWYB led to the increase in the absolute number of B2- and the amount of B-lymphocytes, the absolute number of CD4⁺CD127⁺CD25^- and T-activated lymphocytes, a decrease in the relative number of B1-lymphocytes and lack of fall of the level of T-regulatory cells, which have a positive impact on the clinical course of posttraumatic period in patients of the 2nd group: in 14-th and 30-th day it has increased frequency of relief of inflammatory symptoms as in the group as a whole as per patient and per recovery by 1 month after injury.

проникающее ранение глаза, Бестим, проточная цитофлюориметрия, субпопуляционный состав лимфоцитов, клиническое течение посттравматического периода, a penetrating wound of the eye, Bestim, running cytofluorimetry, subpopulation composition of lymphocytes, the clinical